Tell your doctor if you experience any thigh or groin pain, muscle cramps or twitches, severe or debilitating muscle pain, eye inflammation, or any other adverse effects of concern while you are taking alendronate. Bone 24 (1999): 65-834. Miller PD, Woodson G, Licata AA, Ettinger MP, Mako B, Smith ME, Wang LX, Yates J, Melton ME, Palmisano JJ "Rechallenge of patients who had discontinued alendronate therapy because of upper gastrointestinal symptoms."

Alendronate side effects. This is not a complete list of side effects and others may occur. Beauchesne MF, Miller PF "Etidronate and alendronate in the treatment of postmenopausal osteoporosis." Peter CP "Upper gastrointestinal ulceration with alendronate - Response." N Engl J Med 335 (1996): 1016-2137. Rimmer DE, Rawls DE "Improper alendronate administration and a case of pill esophagitis." J Clin Oncol 11 (1993): 1618-2338. Chesnut CH 3rd, McClung MR, Ensrud KE, Bell NH, Genant HK, Harris ST, Singer FR, Stock JL, Yood RA, Delmas PD, et al "Alendronate treatment of the postmenopausal osteoporotic woman: effect of multiple dosages on bone mass and bone remodeling." Other side effects include: arthralgia, myalgia, and ostealgia. PRECAUTIONS: Before taking alendronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies . Am J Gastroenterol 91 (1996): 1282-312.

Digest Dis Sci 44 (1999): 312-333. See below for a comprehensive list of adverse effects. Digest Dis Sci 44 (1999): 311-229.

Clin Ther 20 (1998): 648-607. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Bone 15 (1994): 415-717. Maconi G, Porro GB "Multiple ulcerative esophagitis caused by alendronate."

Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Graham DY, Malaty HM "Alendronate and naproxen are synergistic for development of gastric ulcers." Ravn P, Bidstrup M, Wasnich RD, et al. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Solomon DH, Patrick A, Brookhart MA "More on reports of esophageal cancer with oral bisphosphonate use." McClung M, Clemmesen B, Daifortis A, et al.

All rights reserved. Ringe JD "The interpretation of preclinical data in predicting bisphosphonate response in the treatment of osteoporosis." Learn about side effects, warnings, dosage, and more. You should not take alendronate if you haveproblems with your esophagus, or low levels of calcium in your blood.Do not take alendronate if you cannot situpright or stand for at least 30 minutes after taking the medicine.Alendronate can cause serious problems inthe stomach or esophagus. Levine J, Nelson D "Esophageal stricture associated with alendronate therapy." Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

They may advise discontinuation of alendronate.

Arch Intern Med 160 (2000): 517-252. Ann Pharmacother 43 (2009): 547-8Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Adami S, Mian M, Gatti P, Rossini M, Zamberlan N, Bertoldo F, Lo Cascio V "Effects of two oral doses of alendronate in the treatment of Paget's disease of bone." Bauer DC, Black D, Ensrud K, Thompson D, Hochberg M, Nevitt M, Musliner T, Freedholm D "Upper gastrointestinal tract safety profile of alendronate - The Fracture Intervention Trial." Wallace JL "Upper gastrointestinal ulceration with alendronate." N Engl J Med 333 (1995): 1437-438. "Alendronate and estrogen-progestin in the long-term prevention of bone loss: four-year results from the early postmenopausal intervention cohort study: a randomized, controlled trial." Isik A, Uras I, Uyar ME, Karakurt F, Kaftan O "Alendronate-induced asthma." Call your doctor for medical advice about side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Some side effects may occur that usually do not need medical attention. Liberman UA, Weiss SR, Broll J, et al. Nussbaum SR, Warrell RP Jr, Rude R, Glusman J, Bilezikian JP, Stewart AF, Stepanavage M, Sacco JF, Averbuch SD, Gertz BJ "Dose-response study of alendronate sodium for the treatment of cancer- associated hypercalcemia." Liberman UA, Hirsch LJ "Esophagitis and alendronate." If usage of alendronate sodium causes any undesirable side effects, contact your doctor. Cerner Multum, Inc. "Australian Product Information." Mbekeani JN, Slamovits TL, Schwartz BH, Sauer HL "Ocular inflammation associated with alendronate therapy." Adverse effects usually have been mild when patients adhered to prescribing instructions.1. O 04. Most side effects are temporary, but some can be permanent or serious.

While most side effects will resolve on their own, some side effects … "Product Information. Cummings SR, Black DM, Thompson DE, et al. Castell DO ""Pill esophagitis"--the case of alendronate." Lourwood DL "The pharmacology and therapeutic utility of bisphosphonates." "Alendronate prevents postmenopausal bone loss in women without osteoporosis: a double-blind, randomized, controlled trial."

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