The chemical name for Ketorolac tromethamine is (±)-5-Benzoyl-2,3-dihydro-1Ketorolac tromethamine is a racemic mixture of [-]S and [+]R Ketorolac tromethamine. There is no evidence in animal or human studies that Ketorolac Tromethamine induces or inhibits hepatic enzymes capable of metabolizing itself or other drugs.In a study involving 12 adult volunteers, oral Ketorolac Tromethamine was coadministered with a single dose of 25 mg The effects of warfarin and NSAIDs, in general, on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than the users of either drug alone.When Ketorolac Tromethamine is administered with aspirin, its protein binding is reduced, although the clearance of free Ketorolac Tromethamine is not altered. Use with caution in patients with impaired renal function or a history of kidney disease.

Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.This is not an exhaustive list of possible drug interactions. There was little difference in the CLimited information is available regarding the pharmacokinetics of dosing of Ketorolac tromethamine in the pediatric population. After a single administration of 10 mg of oral Ketorolac, the maximum milk concentration observed was 7.3 ng/mL, and the maximum milk-to-plasma ratio was 0.037. At the higher recommended doses, there is a proportional increase in the concentrations of free and bound racemate.The mean apparent volume (Vβ) of Ketorolac Tromethamine following complete distribution was approximately 13 liters. Ketorolac Tromethamine has a pKa of 3.5 and an n-octanol/water partition coefficient of 0.26. Patients on long-term treatment with NSAIDs, including Ketorolac tromethamine, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia. Ketorolac tromethamine is a racemic mixture of [-]S and [+]R ketorolac tromethamine. All the risks and benefits should be discussed with the doctor before taking this medicine.This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Gastrointestinal bleeding can occur. Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this population.NSAIDs should be given with care to patients with a history of inflammatory bowel disease (ulcerative colitis, Crohn's disease) as their condition may be exacerbated.Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet aggregation as well, use of Ketorolac tromethamine in patients who have coagulation disorders should be undertaken very cautiously, and those patients should be carefully monitored. You should consult your doctor about all the possible interactions of the drugs you’re taking.Take this medicine exactly as prescribed by the doctor. Medicine Name The sterile solutions are clear to slightly yellow in color.Ketorolac Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic activity in animal models. ulceration, bleeding and perforation, postoperative bleeding, acute renal failure, anaphylactic and anaphylactoid reactions and liver failure (see In patients taking Ketorolac tromethamine or other NSAIDs in clinical trials, the most frequently reported adverse experiences in approximately 1% to 10% of patients are:Additional adverse experiences reported occasionally (<1% in patients taking Ketorolac tromethamine or other NSAIDs in clinical trials) include:Other rarely observed reactions (reported from post-marketing experience in patients taking Ketorolac tromethamine or other NSAIDs) are:Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting and epigastric pain, which are generally reversible with supportive care. Increasing the dose of Ketorolac tromethamine tablets beyond a daily maximum of 40 mg in adults will not provide better efficacy but will increase the risk of developing serious adverse events.Ketorolac tromethamine is CONTRAINDICATED as prophylactic analgesic before any major surgery.Gastrointestinal Effects – Risk of Ulceration, Bleeding and PerforationTo minimize the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration.Status Post Coronary Artery Bypass Graft (CABG) Surgeryadvise patients not to give Ketorolac tromethamine tablets to other family members and to discard any unused drug.digoxin, warfarin, ibuprofen, naproxen, piroxicam, acetaminophen, phenytoinACE inhibitors and/or angiotensin II receptor antagonistsCarcinogenesis, Mutagenesis and Impairment of FertilityCarefully consider the potential benefits and risks of Ketorolac tromethamine and other treatment options before deciding to use Ketorolac tromethamine.

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