Chemically, it is 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4] oxazepine. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Daily dosage higher than 250 mg is not recommended.For maintenance therapy, dosage should be reduced to the lowest level compatible with symptom control; many patients have been maintained satisfactorily at dosages in the range of 20 mg to 60 mg daily.Loxapine Capsules, USP are available containing Loxapine succinate, USP 13.6 mg, 34 mg or 68 mg equivalent to 10 mg, 25 mg or 50 mg of Loxapine base, respectively.The 10 mg capsule is a hard-shell gelatin capsule with an olive opaque cap and a yellow opaque body filled with white to off-white powder. However, Loxapine and its metabolites have been shown to be transported into the milk of lactating dogs. Severe hypotension might be expected to respond to the administration of norepinephrine or phenylephrine. The capsule is axially printed with NDC 51079-901-20 – Unit dose blister packages of 100 (10 cards of 10 capsules each).The 25 mg capsule is a hard-shell gelatin capsule with an olive opaque cap and a light green opaque body filled with white to off-white powder.

The usual therapeutic and maintenance range is 60 mg to 100 mg daily. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. In the presence of severe hypotension requiring vasopressor therapy, the preferred drugs may be norepinephrine or angiotensin. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. Therefore, ambulatory patients should be warned about activities requiring alertness (e.g., operating vehicles or machinery) and about concomitant use of alcohol and other CNS depressants.Loxapine has not been evaluated for the management of behavioral complications in patients with mental retardation, and therefore, it cannot be recommended.Loxapine capsules may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries. The possibility of occurrence of extrapyramidal symptoms and/or convulsive seizures should be kept in mind. CONTRAINDICATIONS.

You should not use loxapine if you are allergic to loxapine or amoxapine, or if you have decreased alertness caused by taking certain medications or drinking alcohol. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Call your doctor if your symptoms do not improve, or if they get worse while using loxapine.Store at room temperature away from moisture, heat, and light.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. lip smacking or puckering. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) Use with caution in any patient with other types of pulmonary disease. 40 Aluminum Lake, propylene glycol, and shellac glaze.Pharmacologically, Loxapine is an antipsychotic for which the exact mode of action has not been established. In addition, emesis should be avoided because of the possibility of aspiration of vomitus.

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