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2018, Substance Abuse and Mental Health Services Administration. This list does not include all possible side effects.For more information on the possible side effects of Provigil, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.The more common side effects of Provigil can include:Some people may also experience less frequent side effects, such as:Serious side effects from Provigil aren’t common, but they can occur. If you feel lightheaded, confused, or sleepy after taking it, don’t drive or use dangerous equipment.Although Provigil helps reduce sleepiness in people with narcolepsy or other conditions, it may not provide full wakefulness. Aspirin. Although rare, some people have had thoughts of suicide, symptoms of psychosis (such as delusions or hallucinations), mania, and aggression. The most common withdrawal symptom from the medication is sleepiness in people who have narcolepsy. The following information is NOT intended to endorse any particular medication. Provigil does not have alpha-adrenergic effects, but the alpha-adrenergic antagonist prazosin can decrease the wakefulness effects of Provigil.Provigil dopamine reuptake does not have dopamine receptor agonist activity. However, the generic version of Provigil costs less than Vyvanse. In fact, Nuvigil is called an “isomer” of Provigil. Modalert isn’t sold in the United States.For most people who take Provigil as prescribed by their doctor, it continues to work even when taken for long periods of time.However, if you feel that it’s no longer working for you, talk to your doctor. Indicated to improve wakefulness in adults with excessive sleepiness associated with obstructive sleep apnea (OSA)Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day doseIndicated to improve wakefulness in adults with excessive sleepiness associated with narcolepsyDoses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day doseIndicated to improve wakefulness in adults with excessive sleepiness associated with shift work disorder (SWD)200 mg PO as a single dose ~1 hr prior to patient's work shiftOrphan designation of a fixed dose combination of modafinil and flecainide for narcolepsyRisk of skin reactions (eg SJS, toxic necrolysis, and drug rash with eosinophilia and systemic symptoms); discontinue if rash or other hypersensitivity reactions occurMay impair ability to operate heavy machinery and perform hazardous tasksNot recommended in patients with angina, cardiac ischemia, recent history of myocardial infarction, left ventricular hypertrophy, or mitral valve prolapseUse with caution in severe hepatic impairment, elderly, history of: depression, psychosis (may exacerbate psychiatric symptoms), or maniaUse with caution in patients with Tourette syndrome; stimulants may unmask ticksMay reduce effectiveness of steroidal contraceptives 1 month after discontinuation of drug therapyReassess degree of sleepiness frequently; if used adjunctively with continuous positive airway pressure (CPAP): Periodic assessment of CPAP compliance is necessaryDiscontinue therapy if symptoms suggest angioedema or anaphylaxisDiscontinue if multiorgan hypersensitivity reaction is suspectedWell controlled studies in pregnant women have not been performedIntrauterine growth restriction and spontaneous abortion have been reported with modafinil and armodafinilIn studies conducted in rats (modafinil, armodafinil) and rabbits (modafinil), developmental toxicity was observed at clinically relevant plasma exposuresPregnancy registry to collect information on pregnancy outcomes of women exposed to modafinil: 866-404-4106A: Generally acceptable. All medications used to treat diabetes. 2001 Keep taking Cardizem (diltiazem tablets) as you have been told by your doctor or other health care provider, even if you feel well. Higher doses are sometimes used, up to 400 mg daily. For instance, some can interfere with how well a drug works, while others can cause increased side effects.Below is a list of medications that can interact with Provigil. This date is typically one year from the date the medication was dispensed.These dates are set to guarantee the effectiveness of the medication during this time.How long a medication remains good can depend on many factors, including how and where the medication is stored. Few reports have been made of arrhythmic events associated with modafinil use. However, these doses may not be any more effective than 200 mg daily.For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.If you have severe liver problems, your doctor will likely prescribe a lower dosage. Dosage of drugs is not considered in the study.

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