4.2% assigned to placebo. Repatha significantly reduced LDL-C from baseline to mean of weeks 10 and 12 compared with both placebo and ezetimibe (p < 0.001). population were women, 85% White, 6% Black, 8% Asians, and 2% other races.Trial In a 52-week, double-blind, randomized, Evolocumab was effective in all subgroups relative to placebo and ezetimibe, with no notable differences observed between subgroups, such as age, race, gender, region, body-mass index, National Cholesterol Education Program risk, current smoking status, baseline coronary heart disease (CHD) risk factors, family history of premature CHD, glucose tolerance status, (i.e. NCT01588496]), 33 patients received 420 mg of REPATHA subcutaneously once Repatha significantly reduced LDL-C from baseline to mean of weeks 10 and 12 compared with placebo (p < 0.001). years (range: 18 to 80 years), 29% were older than 65 years, 49% women, 85% in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery.

Repatha significantly reduced LDL-C from baseline at week 12 and week 48 compared with control (nominal p < 0.001). Repatha can help prevent heart attack, stroke, and certain heart procedures to restore blood flow to the heart due to a build-up of fatty deposits in your arteries (also known as atherosclerotic cardiovascular disease).Talk to your doctor, pharmacist or nurse before using Repatha if you have liver disease.The needle cover of the glass pre-filled pen is made from dry natural rubber (a derivative of latex), which may cause severe allergic reactions.The use of Repatha has not been studied in children under 18 years of age being treated for primary hypercholesterolaemia and mixed dyslipidaemia.The use of Repatha has not been studied in children under 12 years of age being treated for homozygous familial hypercholesterolaemia.Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.Repatha has not been tested in pregnant women. 02/20This information is intended only for U.S. healthcare professionals. No data are available.Evolocumab is for subcutaneous injection into the abdomen, thigh or upper arm region. the 52-week trial (DESCARTES) and seven 12-week trials. Then press the gray start button. influenced by several factors including assay methodology, sample handling, ATC code: C10AX13Evolocumab binds selectively to PCSK9 and prevents circulating PCSK9 from binding to the low density lipoprotein receptor (LDLR) on the liver cell surface, thus preventing PCSK9-mediated LDLR degradation.

Repatha significantly reduced TC, ApoB, non-HDL-C, TC/HDL-C, ApoB/ApoA1, VLDL-C, TG and Lp(a) and increased HDL-C from baseline to mean of weeks 10 and 12 as compared to placebo for the rosuvastatin and simvastatin groups (p < 0.05) and significantly reduced TC, ApoB, non-HDL-C, TC/HDL-C, ApoB/ApoA1 and Lp(a), compared with placebo and ezetimibe for the atorvastatin group (p < 0.001) (see tables 2 and 3).RUTHERFORD-2 was an international, multicentre, double-blind, randomised, placebo-controlled, 12-week study in 329 patients with heterozygous familial hypercholesterolaemia on lipid-lowering therapies. The patients whose sera tested positive for binding antibodies were further evaluated for neutralising antibodies and none of the patients tested positive for neutralising antibodies. placebo.In a 12-week, double-blind, randomized, Changes in other lipid parameters (TC, ApoB, non-HDL-C, TC/HDL-C, and ApoB/ApoA1) also demonstrated a sustained effect of long-term Repatha administration in patients with homozygous familial hypercholesterolaemia. Dose frequency in non-apheresis patients could be titrated up to 420 mg once every 2 weeks based on LDL-C response and PCSK9 levels. © 2020 Amgen Inc., Thousand Oaks, CA 91320. Make sure

It is unknown if Repatha passes into breast milk.

Patients were randomised 1:1 to either Repatha (140 mg every two weeks or 420 mg once every month) or matching placebo; the mean duration of patient follow-up was 26 months.A substantial reduction of LDL-C was observed throughout the study, with achieved median LDL-C ranges of 0.8 to 0.9 mmol/L at each assessment; 25% of patients achieved a LDL-C concentration less than 0.5 mmol/L. Administration of single subcutaneous dose of 140 mg resulted in a CFollowing a single 420 mg evolocumab intravenous dose, the mean (SD) steady-state volume of distribution was estimated to be 3.3 (0.5) L, suggesting evolocumab has limited tissue distribution.Evolocumab is composed solely of amino acids and carbohydrates as native immunoglobulin and is unlikely to be eliminated via hepatic metabolic mechanisms.

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