To purchase short term access, please sign in to your Oxford Academic account above. 2. is Director of Pharmacy, Pharmacy, Winter Haven Hospital Your comment will be reviewed and published at the journal's discretion. Outpatient parenteral antimicrobial therapy with ceftolozane/tazobactam in continuous infusion for multidrug resistant Further investigations on nephrotoxicity in patients on both vancomycin and acyclovir are warranted.Oxford University Press is a department of the University of Oxford. (%) or median [interquartile range].Abbreviations: ACE, angiotensin-converting enzyme; NSAID, nonsteroidal anti-inflammatory drug. Ideal body weight (IBW) also may be used to determine doses for This article is also available for rental through DeepDyve. In addition, each tablet contains the inactive ingredients colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, povidone and sodium starch glycolate. However, only 17 (15%) patients had positive microbiological results, with the most commonly identified organism being HSV. Thank you for submitting a comment on this article. You could not be signed in. The purpose of this study was to determine the prevalence of and risk factors associated with acyclovir-induced nephrotoxicity.A retrospective case–control of patients who received intravenous acyclovir for >48 hours at the University of Mississippi Medical Center over a 4-year period were evaluated to elucidate the prevalence of acyclovir-induced nephrotoxicity. Categorical data were analyzed using the chi-square or Fisher exact test, and continuous data were analyzed using the Student A total of 115 patients were enrolled in the study. Although obesity was the only comorbidity difference between the cases and controls, the total daily acyclovir dosage did not differ between the 2 groups. Katie E Barber, Jamie L Wagner, Kayla R Stover, Impact of Obesity on Acyclovir-Induced Nephrotoxicity, Obesity is a major medical issue nationally, with rates continually increasing. Your comment will be reviewed and published at the journal's discretion. National rates indicate that >35% of adults are obese, with states where large portions of the population have low access to care, including Louisiana, Mississippi, Alabama, and West Virginia, each reporting even higher rates [Although some weight-based antimicrobials have recommendations for use of either actual body weight (ABW) or ideal body weight (IBW), many of these drugs have little evidence available to guide clinician dosing. Search for other works by this author on: Additionally, risk factors for the development of nephrotoxicity, including the effect of obesity and dosing strategy, were assessed.One hundred fifteen patients were included in the study. Search for other works by this author on: 1 At the same time, however, the altered physiology of obesity may have significant effects on the pharmacokinetics (PK) of antimicrobials sufficient to require altered dosing regimens. The drug may be administered topically to the skin, intravenously, orally, or topically to the eye (only topical and … In multivariate logistic regression, both obesity (OR, 2.67; 95% CI, 1.04–6.86) and receipt of vancomycin (OR, 4.06; 95% CI, 1.40–11.80) were independently associated with increased nephrotoxicity (Multivariate Analysis for Independent Risk Factors for Acyclovir-Associated NephrotoxicityAbbreviations: CI, confidence interval; OR, odds ratio.Multivariate Analysis for Independent Risk Factors for Acyclovir-Associated NephrotoxicityAbbreviations: CI, confidence interval; OR, odds ratio.Approximately one-fifth of the patients included developed acyclovir-associated nephrotoxicity after approximately 5 days of therapy. Background: The current recommendations for intravenous (IV) acyclovir dosing in obese patients suggest using ideal body weight (IBW) rather than total body weight (TBW). Normal Respiratory Flora as a Cause of Community-Acquired Pneumonia A total of 24 (21%) patients developed nephrotoxicity after acyclovir exposure and were in the Risk (9.6%), Injury (4.3%), and Failure (7%) categories, defined by the RIFLE criteria.

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