On the other hand, other drugs decrease theophylline clearance, making a reduction in the dose of concurrent theophylline advisable: with usual doses of erythromycin, propranolol and isoprenaline (isoproterenol), a reduction of about 25% is needed; with cimetidine and oral contraceptives by about 30% or more; and with triacetyloleandomycin (troleandomycin) by about 50%. This site needs JavaScript to work properly. Clipboard, Search History, and several other advanced features are temporarily unavailable. * Refer to PRECAUTIONS, Drug Interactions for information regarding table. 1999 Sep;48(3):438-44. doi: 10.1046/j.1365-2125.1999.00043.x.Eur J Drug Metab Pharmacokinet. Plasma levels of theophylline can be altered by concomitant use with liver enzyme-inhibiting drugs such as verapamil, ciprofloxacin, fluconazole, erythromycin, clarithromycin, allopurinol, or cimetidine, or liver enzyme-inducing drugs such as primidone, phenobarbital, carbamazepine, phenytoin, ritonavir, rifampicin, or St John's Wort. In order for us to best serve you and provide you with the best information, can you please tell us if you currently have health insurance? In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. Consult your healthcare professional (e.g., … Do not start, stop, or change the dosage of any medicine without checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. Taking theophylline with allopurinol can increase the level of theophylline in your blood, which can cause dangerous side effects. Examples of drugs not found to have a significant effect on theophylline pharmacokinetics are ranitidine, josamycin, midecamycin, amoxycillin, tetracycline, cephalexin, cefaclor, orciprenaline, metoprolol, antacids, medroxyprogesterone acetate, metoclopramide and metronidazole. In the case of rifampicin, isoniazid or sulphinpyrazone comedication, an increase of the theophylline dose by about 20 to 25% may be needed. theophylline oral brand names and other generic formulations include: Aerolate 111 Oral, Aerolate III TD Oral, Aerolate Jr Oral, Aerolate Sr Oral, Aquaphyllin Oral, Asmalix Oral, Bronkodyl Oral, Bronkodyl Sr Oral, Constant-T Oral, Elixophyllin Oral… ... Theophylline and isoniazid Article These medications are not usually taken together. Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. Please enable it to take advantage of the complete set of features! Some are from the same therapeutic group as the drugs mentioned above and offer clinical alternatives for coadministration with theophylline. The dose of your medicines may need adjusting. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Serious. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Most of the drugs discussed in this review appear not to affect the volume of distribution of theophylline significantly. No change in theophylline clearance was found with the concomitant use of allopurinol but 1‐methylxanthine (1MX), a theophylline metabolite not previously described in man, was detected in urine during control and allopurinol treatment phases under both single‐ and multiple‐dosing conditions. This tool may not cover all possible drug interactions. 11 minor drug interactions. Lexi-Comp, Inc.; April 28, 2007. These interactions are harmful. 1991 Jan;20(1):66-80. doi: 10.2165/00003088-199120010-00005.J Allergy Clin Immunol.
Conflicting results have been reported on the influence of frusemide (furosemide) and influenza vaccines, while data regarding the effect of corticosteroids, benzodiazepines and verapamil on theophylline kinetics are not yet conclusive. Does Theophylline ANHYDROUS Interact with other Medications? High doses of allopurinol taken for more than two weeks may increase the chance for harmful effects. The information provided here is for informational purposes only. doi: 10.2165/00003088-198409040-00002. Inhibition of theophylline metabolism by long-term allopurinol administration. St. Louis, MO: Forest Pharmaceuticals, Inc.;2004 September.Theo-24 [package insert].
This site does not dispense medical advice or advice of any kind. Smyrna, GA: UCB Pharma, Inc.;2005 April.Uniphyl [package insert].
doctor or pharmacist) as soon as possible about taking these two medicines together. 1986 Oct;78(4 Pt 2):736-42. doi: 10.1016/0091-6749(86)90054-0.Clin Pharmacokinet. Clin Pharmacokinet. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage, … ... All generic drug interactions for theophylline oral (lists will include brand and generic names): 5 contraindicated drug interactions;
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