If diarrhea is severe or lasts more than 2 or 3 days, patients should contact their physician. The areas under the serum concentration curves obtained during the first 4 hours after dosing were 12.6 mcg*h/mL for amoxicillin and 2.9 mcg*h/mL for clavulanic acid when 5 mL of 250 mg/62.5 mg/5 mL suspension of amoxicillin and clavulanate potassium or equivalent dose of 10 mL of 125 mg/31.25 mg/5 mL suspension of amoxicillin and clavulanate potassium were administered to normal adults. Amoxicillin clavulanate potassium combination is used in the lowest dose to bring down the adverse gastrointestinal drug effects. Thus, amoxicillin and clavulanate potassium should not be administered to patients with mononucleosis.The possibility of superinfections with fungal or bacterial pathogens should be considered during therapy. These forms contain an amoxicillin to clavulanate ratio of 5 to 1. Amoxicillin and clavulanate potassium is a combination penicillin-class antibacterial and beta‑lactamase inhibitor indicated for treatment of the following: Lower respiratory tract infections



Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.During pregnancy, this medication should be used only when clearly needed. The 250 mg/125 mg tablet of amoxicillin and clavulanate potassium and the 250 mg/62.5 mg chewable tablet should Dosing of amoxicillin and clavulanate potassium should be modified in pediatric patients aged < 12 weeks (< 3 months) [see Dispense in tightly closed, moisture-proof containers. The clavulanic acid in amoxicillin and clavulanate potassium formulation prevents amoxicillin degradation by β-lactamase enzymes. They are supplied in plastic bottles of 20 and 100 (with desiccant) as under: Amoxicillin and clavulanate potassium for oral suspension, USP 200 mg/28.5 mg per 5 mL (each 5 mL of reconstituted caramel-orange-raspberry-flavored suspension contains 200 mg amoxicillin and 28.5 mg clavulanic acid as the potassium salt) are supplied as under: Amoxicillin and clavulanate potassium for oral suspension, USP 400 mg/57 mg per 5 mL (each 5 mL of reconstituted caramel-orange-raspberry-flavored suspension contains 400 mg amoxicillin and 57 mg clavulanic acid as the potassium salt) are supplied as under: Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. The following information includes only the average doses of this medicine. The average household teaspoon may not hold the right amount of liquid. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens. Do not use it later for another infection unless your doctor tells you to.With prolonged treatment, laboratory and/or medical tests (such as kidney/liver function, complete blood counts) may be performed periodically to monitor your progress or check for side effects.

The most frequently reported adverse event was diarrhea; incidence rates were similar for the 875 mg/125 mg every 12 hours and 500 mg/125 mg every 8 hours dosing regimens (15% and 14%, respectively); however, there was a statistically significant difference (p < 0.05) in rates of severe diarrhea or withdrawals with diarrhea between the regimens: 1% for 875 mg/125 mg every 12 hours regimen versus 2% for the 500 mg/125 mg every 8 hours regimen. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. In one study, the relative bioavailability of clavulanate was reduced when amoxicillin and clavulanate potassium was dosed at 30 and 150 minutes after the start of a high-fat breakfast. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Clavulanic acid is produced by the fermentation of Discuss the risks and benefits with your doctor.This medication passes into breast milk. Diarrhea was defined as either: (a) 3 or more watery or 4 or more loose/watery stools in 1 day; OR (b) 2 watery stools per day or 3 loose/watery stools per day for 2 consecutive days. In addition to adverse reactions reported from clinical trials, the following have been identified during postmarketing use of amoxicillin and clavulanate potassium. Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid.

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