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Bisphosphonates: Mechanism of Action and Role in Clinical Practice REVIEW MATTHEW T. DRAKE, MD, PHD; BART L. CLARKE, MD; AND SUNDEEP KHOSLA, MD Bisphosphonates are primary agents in the current pharmacologi-cal …
QID: (OBQ08.223)
Epub 2020 Mar 17.Osteoporos Int.
Epub 2018 Dec 11.
Date QID:
1991 Dec; 88 (6):2095–2105. Mechanism of Action of Simple Bisphosphonates Simple Bisphosphonates are Metabolized into ATP Analogues . Type in at least one full word to see suggestions list L 3
Type in at least one full word to see suggestions list All bisphosphonate drugs share a common P-C-P "backbone": The two PO 3 ( phosphate ) groups covalently linked to carbon determine both the name "bis phospho nate" and the function of the drugs. It also highlights the newer developments in the field of study of bisphosphonates. inhibition of osteoclasts also infereres with normal bone healing and remodelingzoledronic acid - relatively new and appealing to patients, due to decreased spinal fusion rates in lab animal models (increased fusion mass size, but decreases the actual fusion rate)bisphophonates accumulate in high concentration in bone due to binding affinity to calciumbisphosphonates are ingested by osteoclasts and work by two different methods depending on presence of Non-nitrogen containing bisphosphonates (simple) mechanism vertebral compression fracture in osteoporotic patient standard deviations below that of young healthy adults (T score < 2.5 SD)1 year of treatment with a pharmacologic antiosteoporotic medication, the risk of vertebral fracture decreases by 50-60% effective in reducing the risk of multiple fracturesreduced incidence of skeletal events in multiple myelomaAtypical subtrochanteric and femoral stress fractures Radiographic changes consistent with osteopetrosis
Quand les ostéoclastes résorbent l’os, il y a endocytose des produits de l’os et des bisphosphanates.
C QID: Upgrade to PEAK Mass reproduce only with permission from Mayo Clinic Proceedings. Please enable it to take advantage of the complete set of features! Bisphosphonates can now be distinguished based on their molecular and cellular mechanisms of action.
(OBQ09.262)
In recent years, substantial progress has been made in understanding the mechanism for bisphosphonate suppression of bone turnover.
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Although nitrogen-containing bisphosphonates can induce osteoclast apoptosis, this is not necessary for their inhibition of bone resorption.
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There is now general agreement that the final target of bisphosphonate action is the osteoclast.
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Bisphosphonates can now be distinguished based on their molecular and cellular mechanisms of action. Question Complexity
Bisphosphonate mechanism of action. 795 B D
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