Please check your email for instructions on resetting your password. ), McMaster University, Hamilton, Ont., Canada; the Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia (P.D., L.W.D. The use of doxapram — a respiratory stimulant — was also discouraged because of limited evidence of its safety and efficacy.An external safety monitoring committee reviewed the study data every four to six months during the enrollment phase.
and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Infants were considered to have been randomly assigned at the time the first prescription for study drug was signed.As soon as possible after random assignment, eligible infants received an intravenous loading dose of either 20 mg of caffeine citrate per kilogram of body weight or an equivalent volume of normal saline. Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, ArizonaInternational Pharmaceutical Industry Consultant, Lexington, KentuckyDepartment of Pediatrics, University of Arizona Health Sciences Center, Tucson, ArizonaInternational Pharmaceutical Industry Consultant, Lexington, KentuckyUse the link below to share a full-text version of this article with your friends and colleagues. Ascertainment of this outcome is under way and is expected to be completed by December 2006.

Caffeine reduced weight gain temporarily. Specifically, chronic daily high-dose caffeine administration (25 mg/kg loading dose; 20 mg/kg maintenance dose; caffeine base) in fetal sheep from 0.7 to 0.8 of term (a stage when white matter development is similar to that of preterm infants born at about 27–34 weeks gestational age) did not affect glial cell density (astrocytes, microglia or oligodendrocytes), …

By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of UseCaffeine in preterm infants: where are we in 2020?, Caffeine Citrate for Apnea of Prematurity: A Prospective, Open-Label, Single-Arm Study in Chinese Neonates, Stopping caffeine in premature neonates: how long does it take for the level of caffeine to fall below the therapeutic range?, The Journal of Maternal-Fetal & Neonatal Medicine, Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants, Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions, Does routine prophylaxis with caffeine prevent bronchopulmonary dysplasia in extremely low birth weight infants?, Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism, Caffeine inhibits hypoxia-induced nuclear accumulation in HIF-1α and promotes neonatal neuronal survival, Mechanistic actions of oxygen and methylxanthines on respiratory neural control and for the treatment of neonatal apnea, Caffeine treatment for bronchiolitis-related apnea in the pediatric intensive care unit, Respiratory frequency plasticity during development, Caffeine and Clinical Outcomes in Premature Neonates, Caffeine is a risk factor for osteopenia of prematurity in preterm infants: a cohort study, Caffeine: an evidence-based success story in VLBW pharmacotherapy, Efficacy and Safety of Different Maintenance Doses of Caffeine Citrate for Treatment of Apnea in Premature Infants: A Systematic Review and Meta-Analysis, Developmental Physiology and Pharmacotherapy in Pediatric Surgical Newborns, Sex-specific respiratory effects of acute and chronic caffeine administration in newborn rats, Caffeine citrate – Is it a silver bullet in neonatology?, Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study, Incorporating pharmacodynamic considerations into caffeine therapeutic drug monitoring in preterm neonates, The Role of Caffeine in Noninvasive Respiratory Support, Neurodevelopmental Outcomes in Very Low Birth Weight Infants Using Aminophylline for the Treatment of Apnea, Maternal Caffeine Administration and Cerebral Oxygenation in Near-Term Fetal Sheep,
We did not include patent ductus arteriosus among the short-term outcomes in our study protocol because it had not been suggested previously that methylxanthine therapy altered the rate of ductal closure in the preterm infant. At the doses used in this trial, the incidence of drug-induced toxicity is low. Loading dose: 20 mg/kg administered over at least 30 minutes via IV infusion or over at least 10 minutes via slow IV injection.





With the exception of this committee and the study pharmacists, no one involved in the study or in the care and assessment of outcomes of the infants was aware of the individual treatment-group assignments.The primary outcome of this study is a composite of death, cerebral palsy, cognitive delay, deafness, or blindness at a corrected age of 18 to 21 months. aminophylline for the prevention of apnoea of prematurity in a teaching hospital in South Africa

Atrophic Scar Decadron, Typhoid Fever Symptoms Nexium, How To Pronounce Ranitidine, Koplik Spots Rubella Dramamine, Seroquel Price, Antiviral Effects Coversyl, Neutrogena Rapid Wrinkle Repair Night Moisturizer Ingredients Brand Viagra, Zoloft And Diabetes Metformin, Can You Take Antibiotics While Taking Phentermine Emsam, Vyvanse Definition Aygestin, Pulsatilla For Fibroids Indocin, Neonatal Sepsis Guidelines 2019 Bupropion, Bcbswny Com Ebilling Dilantin, Anti Inflammatory Diet For Pcos Super Avana, Benadryl Dosage For Allergic Reaction Provestra, Can-am 800 Outlander Avodart, Esbl Pneumonia Levitra With Dapoxetine, Postmenopausal Symptoms Of Low Estrogen Isordil, Ipratropium Bromide Uses Maxolon, Growth Stimulating Shampoo Lumigan, Ketoconazole Topical Cream And Alcohol Aleve, Theophylline Drug Card Mentat, Cosmetic Vs Drug Claims Stromectol, Health Canada Cosmetic Regulations Arimidex, How To Use Levolin Respules In Nebulizer Keftab, P2y12 Test Levlen, Cervical Mucus Early Pregnancy Before Period Starlix, FLONASE SENSIMIST Benicar, Lactation Suppression Tegretol, Trimipramine Withdrawal Symptoms Prograf, Campral Side Effects Go Away Arava, Trazodone Reddit High Keftab, Perindopril Ramipril Equivalent Dose Glucotrol Xl, Methotrexate 10 Mg Price In Pakistan, Which Antibiotic Is Best For Asthma? Tetracycline, Talenti Gelato Review Topamax,