Three vitamin D preparations are available on prescription in the UK: Calcipotriol (Dovonex ®) — available as an ointment. There were no data on The effect on calcium metabolism is approximately 100 times less than that of the hormonally active form of vitamin DA dermal carcinogenicity study in mice showed no indications of increased carcinogenic risks. The risk of developing such reactions increases if the recommended total dose is exceeded (see section 4.4).The undesirable effects are listed by MedDra SOC and the individual undesirable effects are listed starting with the most frequently reported. This information is intended for use by health professionalsEach gram of ointment contains 0.05 mg (is equal to 50 micrograms) of calcipotriol.Each gram of ointment contains 10 mg of propylene glycol Calcipotriol Ointment 50micrograms/g is indicated for the topical treatment of mild to moderately severe psoriasis (psoriasis vulgaris).Calcipotriol Ointment 50micrograms/g should be applied to the affected skin on limbs or trunk once or twice daily. There are no data on the effect of calcipotriol therapy on human fertility.Calcipotriol has no or negligible influence on the ability to drive and use machines.Based on the clinical data, approximately 25% of the patients treated with calcipotriol could experience an adverse reaction. This site uses cookies. • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. A pronounced therapeutic effect is generally seen after a maximum of 4-8 weeks. Care should be exercised in patients with other types of psoriasis, since hypercalcaemia has been reported in patients with generalised pustular or erythrodermic exfoliative psoriasis.Serum calcium is normalised when treatment is discontinued.The risk of hypercalcaemia is minimal when the dose recommendations are followed.Calcipotriol should not be used on the face, as it may cause skin irritation. per dose 250 nanograms) if required, dose to be increased every 2–4 weeks. At the beginning of treatment, twice daily (morning and evening) application is recommended. per dose 250 nanograms) if required, dose to be increased every 2–4 weeks.Initially 250 nanograms once daily, increased in steps of 5 nanograms/kg daily (max. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. If it is used together with cream or solution containing calcipotriol, the total weekly dose of calcipotriol should not exceed 5 mg (for example 40 ml scalp solution plus 60 g of cream or ointment) due to the risk of hypercalcaemia (see section 4.4).

For maintenance therapy, the frequency of application may be decreased to once daily, depending on the response.Ointment has to be applied as a thin layer to affected skin with gentle rubbing to cover the affected area until most of the ointment disappears.The maximum amount of ointment applied should not exceed 100 grams per week. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for CALCITRIOL. Under these conditions, calcipotriol can be used during breastfeeding. Calcipotriol has shown maternal and foetal toxicity in rats and rabbits when given by the oral route at doses of 54 μg/kg/day and 12 μg/kg/day, respectively. Calcipotriol (non-branded) — available as an ointment and scalp solution. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. However, total recovery of the tritium label over a 96 hour period ranged from 6.7 to 32.6%, figures maximised by uncorrected chemiluminescence. per dose 250 nanograms), increased in steps of 5 nanograms/kg daily (max. Not known (cannot be estimated from the available data).The estimation of the frequency of adverse reactions is based on pooled analysis of data from clinical studies and spontaneous reporting.Hypersensitivity reactions, including face or periorbital oedema, angioedemaSkin irritation, pruritus, skin burning sensation, erythema, bullous reactions, psoriasis aggravated, (contact) dermatitis, skin exfoliationDry skin, rash (including erythematous, maculo-papular, morbilliform, popular and pustular)Urticaria, skin oedema, seborrheic dermatitis photosensitivity reaction, Reporting suspected adverse reactions after authorisation of the medicinal product is important. erythrodermic exfoliative psoriasis (enhanced risk of hypercalcaemia)generalised pustular psoriasis (enhanced risk of hypercalcaemia)

Initially 15 nanograms/kg once daily (max. For maintenance therapy, the frequency of application …

Occlusion is undesirable for the same reason.UV exposure during treatment with calcipotriol, physicians are recommended to advise patients to limit or avoid excessive exposure to either natural or artificial sunlight. When suggestions are available use up and down arrows to review and ENTER to select. per dose 250 nanograms), increased in steps of 5 nanograms/kg daily (max.

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