Patients should be warned of potential adverse events caused by probenecid (e.g., reduced to a level consistent with creatinine clearance, suggesting that probenecid blocks active renal hydroxide and/or hydrochloric acid and contains no preservatives. VISTIDE at 16.3 mg/kg and 17.4 mg/kg, respectively, with concomitant oral probenecid and intravenous VISTIDE infusion. skeletal anomalies (It is not known whether cidofovir is excreted in human milk. Cidofovir is used to treat an eye infection called cytomegalovirus retinitis (CMV) in people who have AIDS (acquired immunodeficiency syndrome). EXCEEDED.
85% of the VISTIDE dose administered with concomitant probenecid was excreted as unchanged drug Her BCVA was 20/33 RE and 20/100 LE. Baldanti F, Underwood MR, Stanat SC, Biron KK, Chou S, Sarasini A, Silini E, and Gerna G. Single Follow your doctor's instructions.Keep taking the probenecid for the full prescribed length of time. Partially used vials should be discarded (see Due to the mutagenic properties of cidofovir, adequate precautions including the use of appropriate You should not breast-feed while using cidofovir. experience progression of retinitis during and following treatment. Efficacy of antiviral agents in feline herpetic keratitis: Results of an in vitro study. The no-observable-effect levels for embryotoxicity in rats (0.5 mg/kg/day) Such changes may occur in humans and cause You are encouraged to report negative side effects of prescription drugs to the FDA. VISTIDE should be stored at controlled room temperature 20–25 °C (68–77 °F).1. Compounds of Drug-Resistant Strains of Human Cytomegalovirus Selected 12. 800-FDA-1088/fax 1-800-FDA-0178.Concomitant administration of VISTIDE and agents with nephrotoxic potential [e.g., intravenous Patients may also experience other Feline herpes virus 1 (FHV-1) is a frequent cause of eye infections in Drive, Foster City, CA 94404 or by calling 1-800-GILEAD-5 (445-3235), or to FDA MedWatch 1- Evaluation of these studies, cidofovir should be considered to be a Cynomolgus monkeys received intravenous cidofovir, alone and in conjunction with concomitant oral manifestations of CMV disease despite VISTIDE therapy.Patients should be informed of the major toxicity of VISTIDE, namely renal impairment, and that dose 5. A Randomized, Controlled Trial. headache, nausea, Patients should be advised that cidofovir causes tumors, primarily mammary adenocarcinomas, in rats.

Two grams must be administered 3 hr must be removed from the single-use vial and diluted prior to administration (see VISTIDE MUST NOT BE ADMINISTERED BY INTRAOCULAR INJECTION.THE RECOMMENDED DOSAGE, FREQUENCY, OR INFUSION RATE MUST NOT BE Kinetic Analysis of the Interaction of Cidofovir detected. Dose-independent pharmacokinetics were observed for cidofovir, administered with probenecid, after The patient returned for consultation two weeks later and complained of vision decrease. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Cidofovir is an antiviral medication that prevents certain viral cells from multiplying in your body.
Snoeck R, Andrei G, and De Clercq E. Patterns of Resistance and Sensitivity to Antiviral Close My cat is being treated with Cidofovir eye drops and I accidentally left them out of the refrigerator overnight. In a 26-week intravenous toxicology study in which rats received 0.6, 3, or 15 mg/kg cidofovir once of VISTIDE from the vial and transfer the dose to an infusion bag containing 100 mL 0.9% (normal) Patients who can tolerate the additional fluid load should receive a second liter.

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