KEY POINTS Imipenem-cilastatin (Primaxin) is includes a carbapenem antibiotic (imipenem) plus a dehydropeptidase-I (DHP-I) inhibitor (cilastatin) that prevents inactivation of imipenem by renal DHP-I It kills bacteria in a time-dependent fashion by interfering with the bacterial cell wall in susceptible organisms Coverage is broad, including multi-drug resistant Pseudomonas sp.
Acinetobacter
In the case of Escherichia coli and selected strains of
Drug treatment for multidrug-resistant
Multidrug-Resistant , Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii, , Management and prevention of ventilator-associated pneumonia caused by multidrug-resistant pathogens, Treatment options for multidrug-resistant bacteria, Mechanisms of resistance to β-lactams in some common Gram-negative bacteria causing nosocomial infections, A Comparison of Clinical and Microbiological Efficacy of Antibiotic Regimens Against Acinetobacter baumannii, Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options, Nontraditional Dosing of Ampicillin‐Sulbactam for Multidrug‐Resistant Acinetobacter baumannii Meningitis, Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Confronting multidrug-resistant Acinetobacter baumannii: a review, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Low-nutrient R2A medium in monitoring microbiological quality of drinking water, Chemical Industry and Chemical Engineering Quarterly, Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections, Treatment Options for?
Clinical Isolates from a Tertiary Greek Hospital Imipenem is active in vitro against a wide range of gram-positive and gram-negative aerobic and anaerobic bacteria, including most strains which are beta-lactamase producing.
Acinetobacter baumannii Comadia redtenbacheri Imipenem, the first widely used carbapenem antimicrobial agent, was shown in early studies to have good in vitro activity against Enterococcal isolates causing bacteremia in patients hospitalized at Robert Wood Johnson University Hospital from July 1997 through October 1999 were tested.
, Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment, Antimicrobial resistance among gram-negative organisms in the intensive care unit, Severe nosocomial infections with imipenem-resistant Acinetobacter baumannii treated with ampicillin/sulbactam, Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia, We do not retain these email addresses.ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901-0019Comparative Evaluation of Penicillin, Ampicillin, and Imipenem MICs and Susceptibility Breakpoints for Vancomycin-Susceptible and Vancomycin-Resistant Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Comparative Evaluation of Penicillin, Ampicillin, and Imipenem MICs and Susceptibility Breakpoints for Vancomycin-Susceptible and Vancomycin-Resistant Antibacterial activity of imipenem: the first thienamycin antibioticNational Committee for Clinical Laboratory StandardsNational Committee for Clinical Laboratory StandardsNational Committee for Clinical Laboratory StandardsNational Committee for Clinical Laboratory StandardsNational Committee for Clinical Laboratory StandardsNational Committee for Clinical Laboratory StandardsTentative interpretive criteria for in vitro antibacterial susceptibility testing with imipenem Imipenem and Cilastatin for Injection USP Page 3 of 43 and of the patient's clinical condition.
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