Serum digoxin concentrations should be carefully monitored while patients are receiving digoxin and clarithromycin simultaneously.Simultaneous oral administration of clarithromycin tablets and zidovudine to HIV-infected adult patients may result in decreased steady-state zidovudine concentrations.

)), New Zealand White rabbits and cynomolgous monkeys failed to demonstrate any teratogenicity from Clarithromycin. This site uses cookies. This tool may not cover all possible drug interactions. Patient exposure is estimated to be greater than 1 billion patient treatment days for clarithromycin.Injection site phlebitis, injection site pain, vessel puncture site pain, and injection site inflammation are specific to the clarithromycin intravenous formulation.In some of the reports of rhabdomyolysis, clarithromycin was administered concomitantly with statins, fibrates, colchicine or allopurinol (see section 4.3 and 4.4).There have been post-marketing reports of drug interactions and central nervous system (CNS) effects (e.g. Learn about drug interactions between clarithromycin oral and trandolapril-verapamil oral and use the RxList drug interaction checker to check drug combinations. This interaction does not appear to occur in paediatric HIV-infected patients taking clarithromycin suspension with zidovudine or dideoxyinosine. ... Generic Name and Formulations: Clarithromycin 500mg. Electrocardiograms should be monitored for QTc prolongation during co-administration of clarithromycin with these drugs. Embryo-fetal toxicity. On the basis of these criteria, about 2% to 3% of those patients who received 1000mg or 2000mg of clarithromycin daily had seriously abnormal elevated levels of SGOT and SGPT, and abnormally low white blood cell and platelet counts. Some patients have shown clinical signs consistent with digoxin toxicity, including potentially fatal arrhythmias. Table 2 is a compilation of adverse reactions for all formulations including clarithromycin I.V. Dose reduction may need to be considered.The primary route of metabolism for tolterodine is via the 2D6 isoform of cytochrome P450 (CYP2D6).

Concomitant administration of rifabutin and clarithromycin resulted in an increase in rifabutin, and decrease in clarithromycin serum levels together with an increased risk of uveitis.The following drugs are known or suspected to affect circulating concentrations of clarithromycin; clarithromycin dosage adjustment or consideration of alternative treatments may be required.Strong inducers of the cytochrome P450 metabolism system such as efavirenz, nevirapine, rifampicin, rifabutin, and rifapentine may accelerate the metabolism of clarithromycin and thus lower the plasma levels of clarithromycin, while increasing those of 14-OH-clarithromycin, a metabolite that is also microbiologically active. The structural formula is: Figure 1: Structure of Clarithromycin.

Since the microbiological activities of clarithromycin and 14-OH-clarithromycin are different for different bacteria, the intended therapeutic effect could be impaired during concomitant administration of clarithromycin and enzyme inducers.Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, 14-OHclarithromycin, were increased. It is recommended that patients who experience tablet residue in the stool and no improvement in their condition should be switched to a different clarithromycin formulation (e.g. In all species the liver was the primary target organ at toxic doses. Reports of rhabdomyolysis have been received for patients taking clarithromycin concomitantly with these statins. Because of the large therapeutic window for clarithromycin, no dosage reduction should be necessary in patients with normal renal function. Potentiated by CYP3A inhibitors (eg, itraconazole, saquinavir, atazanavir, ritonavir). 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Increased levels have been found in both tonsillar and lung tissue. Co-administration of clarithromycin with sildenafil, tadalafil or vardenafil would likely result in increased phosphodiesterase inhibitor exposure. It exerts its antibacterial action by selectively binding to the 50s ribosomal subunit of susceptible bacteria preventing translocation of activated amino acids. clarithromycin for oral suspension, Taro-Clarithromycin (Clarithromycin for oral suspension, ... to any ingredient in the formulation or component of the container.

Klacid/Klacid MR Klacid/Klacid MR Drug Interactions. Discontinuation of the drug generally resulted in a return to or toward normal results. the extreme high or low limit) for the specified test.

When clarithromycin and digoxin are administered together, inhibition of Pgp by clarithromycin may lead to increased exposure to digoxin. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

It inhibits the intracellular protein synthesis of susceptible bacteria.The 14-hydroxy metabolite of clarithromycin, a product of parent drug metabolism also has antimicrobial activity. ... (eg, verapamil, amlodipine, diltiazem, nifedipine). By continuing to browse the site you are agreeing to our policy on the use of cookies.

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