Edoxaban should be avoided in those with normal renal function (>95 mL/min). When compared with VKAs, which are highly associated with substantial drug‐drug interactions, DOACs impart a lower risk; however, they still have significant risk of interactions. use prohibited. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Green, leafy vegetables and certain vegetable oils contain significant amounts Vitamin K, and their consumption in excess may result in decreased PT-INR. Indication for DOAC 3. All DOACs are currently branded medications; therefore, cost remains a significant barrier to access. %����

Federally funded patients (Medicare, Medicaid, etc) are ineligible for these programs (see DOAC indicates direct oral anticoagulant; and NA, not applicable.DOACs have revolutionized anticoagulant management and are becoming the cornerstone treatment for stroke prevention in AF and VTE prophylaxis and treatment, and the list of other indications is expanding. A subanalysis of the FANTASIIA RegistryNon‐vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunctionOral anticoagulation in patients with liver diseaseDirect oral anticoagulants in chronic liver diseaseThe impact of body weight on rivaroxaban pharmacokineticsBody weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59‐7939) in healthy subjectsDirect oral anticoagulants in patients with nonvalvular atrial fibrillation and low body weightPopulation pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trialAnticoagulation at the extremes of body weight: choices and dosingEffect of extremes of body weight on the pharmacokinetics, pharmacodynamics, safety and tolerability of apixaban in healthy subjectsAssociation of body weight with efficacy and safety outcomes in phase III randomized controlled trials of direct oral anticoagulants: a systematic review and meta‐analysisUse of the direct oral anticoagulants in obese patients: guidance from the SSC of the ISTHPeak plasma concentration of direct oral anticoagulants in obese patients weighing over 120 kilograms: a retrospective studyEfficacy and safety of direct oral factor Xa inhibitors compared with warfarin in patients with morbid obesity: a single‐centre, retrospective analysis of chart dataComparing the efficacy and safety of direct oral anticoagulants with warfarin in the morbidly obese population with atrial fibrillationRivaroxaban presents a better pharmacokinetic profile than dabigatran in an obese non‐diabetic stroke patientIschemic stroke in an obese patient receiving dabigatranEffectiveness and safety of direct oral anticoagulants versus warfarin in obese patients with acute venous thromboembolismBody mass index is an independent predictor of major bleeding in non‐valvular atrial fibrillation patients taking dabigatranLaboratory and clinical monitoring of direct acting oral anticoagulants: what clinicians need to knowLaboratory measurement of the anticoagulant activity of the non‐vitamin K oral anticoagulantsManagement of patients on non‐vitamin K antagonist oral anticoagulants in the acute care and periprocedural setting: a scientific statement from the American Heart Association2017 ACC expert consensus decision pathway for periprocedural management of anticoagulation in patients with nonvalvular atrial fibrillation: a report of the American College of Cardiology Clinical Expert Consensus Document Task ForceThe Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) study for patients on a direct oral anticoagulant who need an elective surgery or procedure: design and rationaleSelect drug‐drug interactions with direct oral anticoagulants: JACC review topic of the weekCost‐effectiveness of oral anticoagulants for ischemic stroke prophylaxis among nonvalvular atrial fibrillation patientsCost‐effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillationBenefit, risk and cost of new oral anticoagulants and warfarin in atrial fibrillation; a multicriteria decision analysisComparison of all‐cause costs and healthcare resource use among patients with newly‐diagnosed non‐valvular atrial fibrillation newly treated with oral anticoagulants

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