2018 May;32(5):915-923. doi: 10.1038/s41433-018-0033-3.

 AKoyuncu

Variables of interest are described as mean ± SD and range.  HDrexler  et al. COVID-19 is an emerging, rapidly evolving situation. All rights reserved.

 JF Variability of ultrasonic pachometry. Konowal

Uva  MRAmyot

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 et al. On the first study day, a baseline CCT measurement was performed using the ACMaster followed by measurement of intraocular pressure (IOP) by Goldmann applanation tonometry.Corneal scans were analyzed after completion of all study measurements.  DOMcLaren  E Ophthalmic laser interferometry. Because dorzolamide is a potent inhibitor of CA II, concerns have been raised that this drug may have an adverse effect on corneal endothelial cell function by inhibiting the bicarbonate pump.In summary, our study revealed corneal thickening induced by 4-week dorzolamide application in patients with a compromised corneal endothelial cell layer. Dorzolamide has been poorly studied in children with glaucoma.

All reported The mean CCT change from baseline to day 28 in the cornea guttata group receiving dorzolamide medication was 26.3 μm (95% confidence interval [CI], 8.8 to 43.7). Gordon  VLongo Eye Itching If experienced, these tend to have a Less Severe expression 1.

 WF Membrane-associated CA activity in the eye of the CA II-deficient mouse. Mean percentage changes are derived from the geometric mean of the corresponding ratios.  BGhosh

 WM Effect of dorzolamide on corneal endothelial function in normal human eyes.

 N Dorzolamide: development and clinical application of a topical carbonic anhydrase inhibitor.  RVogel

Cct measurement Dorzolamide treatment induced a statistically significant decrease in IOP comparing baseline values with values at study days 1, 7, and 28 (None of the included subjects showed signs of corneal decompensation at the slitlamp examination—either at baseline or at day 1, 7, or 28.  ABoggess  JPReibaldi  HMLesk  WBaumgartner Results

 SFindl  ETipping Our study followed the guidelines of the Declaration of Helsinki and was carried out according to European Union Good Clinical Practice guidelines. A compromised endothelial cell layer may not execute this function satisfactorily and allow corneal edema, loss of transparency, and impaired vision.

 RR Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes. Nemeth

 et al.  EJ No statistically significant changes were measured in the healthy control group.  AJGray

You may report side effects to the FDA at 1-800-FDA-1088.Portions of this document last updated: Aug. 01, 2020Copyright © 2020 IBM Watson Health. The chronic corneal thickening had a mean magnitude of 26 μm (4.7% CCT thickening), which is not clinically relevant. Note: This document contains side effect information about dorzolamide ophthalmic. Simpson In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. After the data had been cross-checked and entered into the database, the pharmacy handed over the envelope with the randomization list, the seal was broken, and the medication sequences of the patients were unmasked. Kaminski  EASchuman The reports suggest that dorzolamide can cause irreversible corneal edema in a subset of glaucoma patients with endothelial compromise.

 MGFindl Wistrand The measurements showed a mean increase of 26.3 μm in CCT in the patients with cornea guttata after 28 days. Am J Ophthalmol. Kuang

Pfeiffer  AF Submicrometer precision biometry of the anterior segment of the human eye.  MLonnerholm  et al.  AFMengedoht

 MGRusso

 W Eye length measurement by interferometry with partially coherent light.  et al.

Raised Spots On The Cornea Of The Eye 3.  KAdamsons  MBAllingham

 LWChoudhri

 LEEhinger

No further statistically significant change in CCT—neither in the cornea guttata group with placebo medication, nor in the control group using dorzolamide or placebo—was detected when comparing baseline with day 28.Comparing the groups, we found 2 statistically significant differences from baseline to day 28.

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