172 0 obj <>/Filter/FlateDecode/ID[<7AE0AE4BFEDFD94F8346B46F857BF052><07F0BDBE38A2684ABCD9A7B770679762>]/Index[155 31]/Info 154 0 R/Length 86/Prev 191036/Root 156 0 R/Size 186/Type/XRef/W[1 2 1]>>stream Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.





(2.1) LEVITRA is taken as needed: For most patients, the starting dose is 10 mg, up to once daily. Incidence of Acute Renal Failure (see administration section; hydration.) and formulary information changes. Controlled studies in pregnant women show no evidence of fetal risk.Selective sodium-glucose transporter-2 (SGLT2) inhibitorSGLT-2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen; SGLT2 inhibitors will reduce glucose reabsorption and lower the renal threshold for glucose, thereby increasing urinary glucose excretionPeak plasma time: 2 hr (fasting); ~3 hr (with high fat meal)High fat meal decreases peak plasma concentration by up to 50%CYP-mediated metabolism is a minor clearance pathway in humansExtensively metabolized, primarily to yield dapagliflozin 3-O-glucuronide (inactive metabolite)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. This website also contains material copyrighted by 3rd parties. %PDF-1.6 %���� For example, the DPRF recommended that dose adjustment for bupropion is not required. Renal damage is usually reversible with discontinuation of therapy, and renal function typically returns to baseline within 2 weeks (range, 2-38 days). Medical Societies Advise on Vitamin D in Midst of COVID-19Hyperglycemia Predicts COVID-19 Death Even Without Diabetes Long-term Antibiotic Use Linked to Increased Type 2 Diabetes Risk in WomenManaging Atherosclerotic Cardiovascular Disease in Patients With Type 2 DiabetesShare cases and questions with Physicians on Medscape consult. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC.


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The flexible dose-adjustment approach for oral semaglutide was designed to mimic the individualised approach used in clinical practice, with treatment dose being increased or decreased depending on glycaemic efficacy and gastrointestinal tolerability, rather than the fixed-dose …



/viewarticle/937067 2001 2002 In controlled trials, patients with chronic kidney disease (CKD) such as renal impairment or renal failure experienced greater risks for mortality, myocardial infarction, congestive heart failure, thromboembolism, and stroke when administered epoetin alfa and other erythropoiesis-stimulating agents (ESAs) to a target hemoglobin concentration greater than 11 g/dL.
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Heart Failure. dose adjustment in patients with renal impairment.

dose dependent way. Increase to 20 mg or decrease to 5 mg based on efficacy/tolerability.

Indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure (NYHA class II-IV) with reduced ejection fraction. h�b```e``�b`a``sc�g@ ~�+s,��01�,�O��qt�e�ֿ���,�*�%s���'�>���!�� �%..%--�@},a�L��6_�栴eډ��m,P�5SO�cځ�������.S���v]�� �����Q��������������`����, �A�C��%8�4��t�����f`��1�3�z�6C�����Q�)�E��Oύ�E�����5�� OBJECTIVE —To evaluate the influence of renal impairment on the safety and efficacy of repaglinide in type 2 diabetic patients. endstream endobj startxref /recap/934513 10 mg PO qDay.

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