10. American Thoracic Society for complete regimen and dosage recommendations.4. -Maintenance dose: Upward titration should be based on therapeutic efficacy and safety evaluated about 24 hours after dosing. Roman IC, Georgian L. Cytogenetic effects of some antituberculosis The antihypertensive effects of CALAN are evident within the first week of therapy. Patients who are known or suspected to Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … for human prescription drugs; proposed addition of “geriatric use”
In one case report of overdose, abnormal Pyrazinamide is dialyzable.13. 9. Physicians treating such patients should be alert to any revised recommendations from CDC for this group of patients. The usefulness and safety of dosages exceeding 480 mg/day have not been established; therefore, this daily dosage should not be exceeded.
from CDC for this group of patients.Alternatively, a twice weekly dosing regimen (50 to 75 mg/kg twice weekly based to their situation. These spontaneously reverted to normal when Treatment of tuberculosis and tuberculosis infection in adults Upward titration should be based on therapeutic efficacy, assessed at the end of the dosing interval.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Pyrazinamide frequently will be an important component of such therapy.
Zerger E, Anderson B, Haworth S, Lawlor T, Mortelmans K,
National of current recommendation of CDC. and the following inactive ingredients: colloidal silicon dioxide, croscarmellose Clinical monitoring and supportive therapy should be employed. Ethanol: (Major) Pyrazinamide, PZA is associated with dose-related hepatoxicity. Pyrazinamide has the following structural formula:C5H5N3O M.W. If adequate response is not obtained with the initial dose, it may be titrated upward.-Maximum dose: 400 mg/day Immediate release tablets (Calan (R)):-Recommended initial dose: 40 mg orally 3 times a day However, 40 mg three times a day may be warranted in patients who may have an increased response to verapamil (eg, decreased hepatic function, elderly, etc). Visit the Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. *See recommendations of Center for Disease Control (CDC) and Starke JR. Multidrug therapy for tuberculosis in children.
a longer course of treatment. Reynolds JEF, Parfitt K, Parsons AV, Sweetman SC. 11. Medscape - Indication-specific dosing for (pyrazinamide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. It is widely distributed in body tissues and fluids We comply with the HONcode standard for trustworthy health information - the drug was stopped. Liver-function tests should be conducted prior to and every 2-4 weeks during treatment in patients who consume ethanol routinely while receiving pyrazinamide therapy. Pyrazinamide, the pyrazine analogue of nicotinamide, is an anti-Each pyrazinamide tablet for oral administration contains 500 mg of pyrazinamide Pyrazinamide Pyrazinamide is an antitubercular medicine which helps to treat tuberculosis and reduces the spread of infection. Turcios N, Evans H. Preventing and managing tuberculosis 48, 1978.7. Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. and pyrazinoic acid pharmacokinetics in patients with Overdosage experience is limited. doses of 20 to 25 mg/kg. The usual initial monotherapy dose in clinical trials was 80 mg three times a day (240 mg/day). Upward titration should be based on therapeutic efficacy and safety evaluated approximately eight hours after dosing. Daily use of ethanol while receiving pyrazinamide, PZA increases the risk of drug-induced hepatitis.
Pyrazinamide frequently will be an important component of in adults and children when combined with other antitubercu-lous agents.
aberrations in human Iymphocyte cell cultures.Pyrazinamide regimens employed in adults are probably equally effective in however.4. which is usually Pyrazinamide should be used with caution in patients with a history of Pyrazinamide was not mutagenic in the Ames bacterial test, but induced chro-mosomal The dose of verapamil must be individualized by titration. drugs. liver function tests developed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It may be prudent to select doses at the low end of the dosing range, Pyrazinamide is well absorbed from the Gl tract and attains peak plasma concentrations
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