Background: Rituximab has been associated with hepatitis B virus reactivation (HBV-R). Correspondence: Claire Dysart, PharmD, Department of Veterans Affairs, Clement J. Zablocki Veterans Affairs Medical Center, 5000 W. National Ave., Milwaukee, WI 53295 (



cGastroenterology, Hepatology, and Nutrition, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USAcGastroenterology, Hepatology, and Nutrition, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USAThe article explores the use of lamivudine as prophylaxis for rituximab‐induced hepatitis B.The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. Search for other works by this author on: B‐cell recovery begins around 6 months after treatment and levels may return to normal by 12 months [HBV is a DNA virus belonging to the Hepadnavirus family.





This work is written by (a) US Government employee(s) and is in the public domain in the US. Rituximab is a human-mouse chimeric monoclonal antibody that targets the B-cell CD20 cell surface protein and has become indispensible for the treatment of B-cell non-Hodgkin's lymphoma [1–3]. Clinical implications of misleading test results may include unnecessary antiviral administration, which can result in unintended consequences secondary to acute and/or long-term toxicities as well as unneeded monitoring. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.Department of Veterans Affairs, Clement J. Zablocki Veterans Affairs Medical Center



Hepatitis B reactivation was defined by hepatitis B DNA levels 20 IU/ml (1.30 log/ml) and above. HBV reactivation related to rituximab use is associated with increased morbidity and mortality in oncology practice.


Since that time it has been shown to be a complication of many immunosuppressive drug therapies (ISDTs) that are routinely used across medical specialties for nonmalignant indications.

The median (interquartile range) number of hepatitis B DNA tests performed during treatment, initial six-month follow-up, and subsequent follow-up were 1.0 (0.0–2.6), 1.0 (0.0–2.0), and 1.0 (0.0–3.1), respectively.Large variations in hepatitis B reactivation monitoring and management strategies were observed.
Detroit, Michigan



Assessment for HB exposure yielded a positive HBcAb, and additional laboratory tests including HBV DNA and liver function tests were completed. Prevention of Cardiac Implantable Electronic Device–Related Infection in Patients Living with Cancer: The Role of a Comprehensive Prophylactic Bundle Approach that Includes the Antimicrobial Mesh



Jeryl Villadolid. This Open Access article contains public sector information licensed under the Open Government Licence v2.0 ( The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent.Create a link to share a read only version of this article with your colleagues and friends. This chimeric murine/human monoclonal antibody targets the CD20Rituximab is very well tolerated by the vast majority of patients.

Incidence of Healthcare-Associated COVID-19 During Universal Testing of Medical and Surgical Admissions in a Large US Health System Reactivation can occur spontaneously, but it is more commonly triggered by immunosuppressive (IS) therapies. the site you are agreeing to our use of cookies.

Merry Jennifer Markham.

Serious adverse reactions are rare and include lactic acidosis, severe hepatomegaly with steatosis, and pancreatitis. Search for more papers by this author.

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