Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). Due to the wide therapeutic index of loratadine no clinically relevant interactions are expected and none were observed in the conducted clinical trials (see Section 5.2).A large amount of data on pregnant women (more than 1000 exposed outcomes) indicate no malformative nor feto/ neonatal toxicity of loratadine. Gastric lavage may be considered. There are, however, no adequate and well-controlled studies in pregnant women. An initial dose of 10mg every other day is recommended for adults and children weighing more than 30kg, and for children weighing 30kg or less, 5mg every other day is recommended.No dosage adjustments are required in older people or in patients with renal insufficiency.Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.Loratadine 10 mg Tablets should be administered with caution in patients with severe liver impairment (see section 4.2).The administration of Loratadine 10 mg Tablets should be discontinued at least 48 hours before skin tests since antihistamines may prevent or reduce otherwise positive reactions to dermal reactivity index.This medicinal products contains lactose monohydrate. COMPOSITION QUALITATIVE ET QUANTITATIVE
Doliallergie loratadine 10 mg : informations générales DOLIALLERGIE LORATADINE est indiqué chez l'adulte et l'enfant de plus de 30 kg (environ 12 ans) : il soulage les symptômes associés à la rhinite allergique (par exemple le rhume des foins) tels que les éternuements, l'écoulement nasal clair, le nez et/ou les yeux qui démangent, le larmoiement. LORATADINE TEVA 10 mg, comprimé est indiqué pour soulager les symptômes associés à la rhinite allergique (par exemple, le rhume des foins) tels que les éternuements, le nez qui coule ou qui démange, les yeux qui démangent ou larmoient, chez l’adulte et l’enfant de plus de 2 ans qui pèse plus de 30 kg. DANS TOUS LES CAS, SE CONFORMER STRICTEMENT A L'ORDONNANCE DE VOTRE MEDECIN.

Loratadine and DL achieve maximum plasma concentrations (TIncrease in plasma concentrations of loratadine has been reported after concomitant use with ketoconazole, erythromycin, and cimetidine in controlled trials, but without clinically significant changes (including electrocardiographic).Loratadine is highly bound (97% to 99%) and its active metabolite moderately bound (73% to 76%) to plasma proteins.In healthy subjects, plasma distribution half-lives of loratadine and its active metabolite are approximately 1 and 2 hours, respectively. It is manufactured by Square Pharmaceuticals Ltd.. Patients âgés ou atteint d'insuffisance rénale : Less than 1% of the active substance is excreted unchanged in active form, as loratadine or DL.The bioavailability parameters of loratadine and of the active metabolite are dose proportional.The pharmacokinetic profile of loratadine and its metabolites is comparable in healthy adult volunteers and in healthy geriatric volunteers.Concomitant ingestion of fool can delay slightly the absorption of loratadine but without influencing the clinical effect.In patients with chronic renal impairment, both the AUC and peak plasma levels (CIn patients with chronic alcoholic liver disease, the AUC and peak plasma levels (CLoratadine and its active metabolite are excreted in the breast milk of lactating women.Preclinical data reveal no special hazard based on conventional studies of safety, pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.In reproductive toxicity studies, no teratogenic effects were observed.

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