The groups include a dose of testosterone that is very low, low, medium, high and placebo. ; Ask about testosterone testing. They are also started on oral progesterone, the natural human type.As a woman enters menopause and stops having periods, her estrogen level drops. Studies that have demonstrated benefits of testosterone in women have often used doses of testosterone which resulted in higher than normal serum testosterone levels. After the initial WHI results were posted, there was an immediate 50 percent reduction in hormone prescriptions, and this has permanently biased physicians ever since. During the testosterone treatment phase the women will be separated into 5 groups. Although normal blood levels of testosterone in women are much lower than in men, testosterone is thought to have important physiologic effects in women, particularly on muscle function, body composition, sexual function and cognitive function. In the 16-year follow-up to this Danish study, woman had about a 50 percent reduction in heart attacks and a more than 70 percent reduction in premature deaths.So the WHI, as well as other studies, showed a slightly increased risk of breast cancer in women taking synthetic hormone drugs, and neutral or slight protection against breast cancer when taking actual hormones.But there was a missing link. Their average age was 66. Methyltestosterone is a synthetic testosterone that is also available alone. The dose is generally about 10 mg, which is one-tenth the amount of testosterone. About half the men with low testosterone were treated with testosterone replacement, and the other half were not treated. While a laboratory evaluation is done, treatment decisions are based more on the clinical findings than the lab results. The reduction in breast cancer rates were based on how long the women were on testosterone replacement. It’s absurd but true.Women entering menopause, or getting symptoms of hormone imbalance, do have an option. They found that the higher dose, 25mg, of testosterone tested in this trial after 24 weeks was associated with gains in sexual function, muscle mass and measures of physical performance. Neither the subject nor the investigators will know the dose until the end of the study.In healthy women the primary hormones produced by the ovaries are estrogens and progesterone, but they also produce testosterone both before and after menopause. COVID-19 is an emerging, rapidly evolving situation. Testosterone is commonly thought of as a "male hormone" thus being that it is the male's primary hormone. In the 1980s and ‘90s, doctors were prescribing hormone replacement routinely for women because we knew it protected their hearts, made them feel better, and improved their quality of life. They are using testosterone alone in most women, only occasionally adding estrogen. The decision to get hormone therapy after surgical menopause is personal. That’s an amazing 80 percent reduction in the expected risk of breast cancer!Numerous studies have been published since that time in which testosterone at the dose of about 1 mg per pound of body weight was used as a pellet or implant. INTRODUCTION: Testosterone replacement therapy in naturally and surgically menopausal women is a complex and currently highly debated topic. Testosterone is a dominant hormone in a young healthy woman, about five to 20 times more abundant than estrogen.In 2004, a study was done in Australia adding testosterone pellets to the standard hormone replacement therapy of estrogen and synthetic progestin.They dosed the testosterone at about 1 mg per pound of body weight. We use this to test if the subject is having a response to the testosterone itself or the thought of receiving testosterone. Long-term studies following women for up to 16 years show an over 50 percent reduction in heart attacks and premature death when estrogen is added.In cases where women have been treated for breast cancer, the use of estrogen has been controversial. Women produce testosterone in much smaller amounts and despite this, testosterone still plays a significant role. Here is a 50 percent less chance of dying, more effective than any other drug, and the FDA says it shouldn’t be used except to treat those conditions. It has been assumed that testosterone dose-response relationships are different in women than in men, and that clinically significant effects on psycho-sexual function, body composition, muscle performance, cognitive function, and other health-related outcomes can be achieved at testosterone doses and concentrations that are substantially lower than those required to produce similar effects in men; however, these assumptions have not been tested rigorously.Therefore, the primary objective of this study is to establish testosterone dose-response relationships in surgically menopausal women with low testosterone concentrations for a range of androgen-dependent outcomes, including sexual function, fat-free mass, thigh muscle strength and leg power, several domains of neurocognitive function, plasma lipids, apolipoproteins and lipoprotein particles, and insulin sensitivity.The secondary objective is to determine the range of testosterone doses and subsequent plasma testosterone concentrations that are associated with improvements in sexual, physical and neurocognitive functions and that can be safely administered to women without significant adverse effects on hair growth, voice, sebum production, clitoral size, and cardiovascular risk factors.

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