Diffuse maculopapular eruption, usually sparing faceFever lasting 3 to 4 days, followed within 2 to 3 days by the rash, which resolves spontaneously in several days; almost always a self-limited benign disease; temporal relationship of fever followed by rash is helpful in making the diagnosisMacule or papule at site of tick bite, progressing to pathognomonic erythema migransAll ages at risk for tick exposure in endemic areasHistory of tick exposure; secondary erythematous, macular lesions; Borrelia lymphocytoma; highest incidence: May through SeptemberClinical findings, serology, polymerase chain reaction testDull-red macules developing into papules with central vesicles or bullae; common on dorsa of hands, palms, soles, arms, knees, penis and vulva; often bilateral and symmetricAdults 20 to 30 years of age; men affected more often than womenMajor and minor forms; major form always with mucous membrane involvement and usually the result of drug reaction; minor form often associated with herpes simplex outbreak; rarely life-threateningVarious presentations; brownish-red or pink macules and papules; generalized eruption or localized eruption on head, neck, palms or soles; condyloma lata commonAdolescents and adults 15 to 49 years of age; females affected more often than malesDevelops 2 to 10 weeks after primary chancre; presents with or without fever; may have generalized lymphadenopathy and splenomegaly; may have recurrent eruptions with symptom-free periodsVariety of lesions but, characteristically, petechial lesions distributed on the trunk and extremities (although the lesions can be located anywhere); petechiae on mucous membranesHighest incidence in children 6 months to 1 year of ageAcutely ill patient; high fever, tachypnea, tachycardia, mild hypotension; leukocytosis; meningitis develops in more than 50 percent of patientsIntermittent maculopapular lesions, often on a painful joint or pressure point; may have nodules on calvesFever, myalgias, arthralgias, headache, anorexia; may recur for weeks or months, with average duration of 8 weeks; may progress to acute meningococcemia, meningitis or endocarditisRash evolving from pink macules to red papules and finally to petechiae; rash beginning on wrists and ankles and spreading centripetally; involvement of palms and soles late in diseaseYoung adults with tick exposure; men affected more often than womenOnset typically abrupt; fever, severe headache and myalgias are prominent; rash appearing around fourth day of illness; may have relative bradycardia and leukopeniaPunctate erythema beginning on trunk and spreading to extremities, becoming confluent; flushed face with perioral pallor; rash fading in 4 to 5 days and followed by desquamationAcute infection of tonsils or skin; linear petechiae in antecubital and axillary folds (Pastia's sign); rash appearing 2 to 3 days after infection; initially, “white strawberry tongue” but by fourth or fifth day, “red strawberry tongue”Rapid strep test, wound or throat culture, antistreptolysin O titersDiffuse “sunburn“ rash that desquamates over 1 to 2 weeksHigh fever, hypotension and involvement of three or more organ systems; about 50 percent of cases occurring in menstruating women around onset of menses; postoperative patients at increased risk; condition out of proportion to wound appearanceErythematous rash on hands and feet; morbilliform, scarlatiniform rash on trunk and perineum; hyperemic lipsChildren less than 8 years of age, with peak incidence at 1 year; boys affected more often than girlsWinter and spring; high fevers, cervical lymphadenopathy, arthritis, arthralgias, cardiac involvement, mucous membrane involvement; can be complicated by coronary artery abnormalities in 20 to 25 percent of casesInitially, papules, which evolve into vesicles (“dewdrops on a rose petal”) and eventually into pustules and crusts; rash beginning on face and spreading inferiorly to trunk and extremities90 percent of cases in children less than 10 years of age; 5 percent of cases in persons older than 15 yearsProdrome consisting of headache, general aches, backache and malaise is typically absent in children; exposure history; may have all forms of lesions at the same time; vesicles evolving to shallow erosions common on mucous membranes of palate; may also have vesicles on nasal, conjunctival, gastrointestinal tract and genital mucosaBegins as erythematous maculopapular eruption, rapidly evolves to vesiclesAll ages, but incidence increases with age and immunosuppressionProdrome of unusual skin sensations; dermatomal pattern, with lesions rarely crossing midline; pain often severe; more common in thoracic and facial dermatomesGeneralized maculopapular- vesicular exanthem; possible involvement of mucous membranes; no involvement of palms or solesTransmitted from mice to humans via mites; formation of papules 7 to 10 days after initial bite; typically, formation of a black eschar over healing lesion; febrile phase occurring 3 to 7 days after initial lesion and lasting up to a week; self-limited, usually mild courseBright-red nodules (3 to 20 cm in diameter) scattered bilaterally but not symmetric; most frequently on lower legs but also found on knees and arms; rarely found on face and neck; lesions often tender and induratedAdolescents and young adults 15 to 30 years of age; females affected more often than malesThorough history and physical examination to identify known causes; throat culture for group A beta-hemolytic streptococci; chest radiograph to rule out sarcoidosis; arthralgias present in 50 percent of cases; fever and malaise commonMaculopapular eruptions are most frequently seen in viral illnesses Maculopapular rash in a nonspecific viral exanthem.Maculopapular rash in a nonspecific viral exanthem.Centrally distributed maculopapular eruptions are more common than peripheral eruptions.The exanthem of rubeola begins around the fourth febrile day, with discrete lesions that become confluent as they spread from the hairline downward, sparing the palms and soles.

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