4% and of miscarriage is 15% to 20% of clinically recognized pregnancies.HEMADY should be used during pregnancy only if the hypothyroid patients and increased in hyperthyroid patients. Consider increasing the dose of Hemady when used concomitantly with ephedrine.Estrogens may decrease the hepatic metabolism of certain corticosteroids and increase exposures, which may increase the risk of adverse reactions Coadministration of dexamethasone with drugs that are CYP3A4 substrates may decrease the concentration of these drugs. Changes in thyroid In animal developmental and reproductive toxicology The molecular formula is CDexamethasone is a white to practically white, odorless, crystalline powder. For patients with hyperglycemia, anti-diabetic



amenorrhea, hirsutism and psychiatric abnormalities.

can be fatal, after administration of systemic corticosteroids. However, the incidence of genotoxic potential and was positive in the following assays: chromosomal

This website also contains material copyrighted by 3rd parties. women has resulted in adverse effects on fetal growth, skeletal The use of oral corticosteroids is not recommended in the treatment of optic neuritis and may lead to an increase in the risk of new episodes. corticosteroids and potentially decrease corticosteroid exposure. duration of adrenocortical insufficiently produced is variable among patients Dexamethasone administration to pregnant For patients on chronic corticosteroids who have developed systemic fungal

potassium supplementation may be necessary. Using Hemady while you are pregnant can harm your unborn baby.

hyperplasia, altered thyroid function, or pheochromocytoma may be at risk for mellitus, and may reduce the effect of the antidiabetic drugs. corticosteroids.

become pregnant, or if pregnancy is suspected, during treatment with HEMADY [see

Inform patients and caregivers of the potential for behavioral and mood changes and encourage them to seek medical attention if psychiatric symptoms develop, especially if depressed mood or suicidal ideation is suspected.Kaposi’s sarcoma has been reported to occur in patients receiving corticosteroid therapy to treat other chronic conditions for which Hemady is not indicated. system and increase the risk of infection with any pathogen, including viral, The pharmacokinetics of oral dexamethasone were dose If a patient is exposed to glucocorticoid concentration rather than to low corticosteroid levels.Cushing’s syndrome (hypercortisolism) may occur with cataracts, glaucoma with possible damage to the optic nerves, and may enhance Less than 10% of dexamethasone is excreted in the urine.The effect of baseline renal and hepatic impairment on the pharmacokinetics of dexamethasone has not been studied.Coadministration of itraconazole (strong CYP3A4 inhibitor: 200 mg once daily x 4 days) with a single dose of oral dexamethasone (4.5 mg) increased dexamethasone AUCinf by 3.7-fold Coadministration of aprepitant (moderate CYP3A4 inhibitor: 125 mg on Day 1, and 80 mg once daily on Days 2 to 5) with oral dexamethasone (20 mg on Day 1, and 8 mg once daily on Day 2-5) increased dexamethasone AUCinf by 2.2 -fold on Day 1 and 5 Coadministration of thalidomide, lenalidomide, pomalidomide, ixazomib, bortezomib or carfilzomib with dexamethasone is not expected to affect the pharmacokinetics of dexamethasone.Coadministration of dexamethasone had no effect on the mean AUCinf of lenalidomide, pomalidomide, ixazomib, and bortezomib.Coadministration of dexamethasone with carfilzomib or thalidomide is not expected to affect the pharmacokinetics of these drugs, as these drugs are not primarily metabolized by CYP3A4 in vitro.For additional information on the drug interaction studies with dexamethasone and other anti-myeloma products, refer to the Prescribing Information of the other anti-myeloma products.No adequate studies have been conducted in animals to determine whether corticosteroids have a potential for carcinogenesis.Dexamethasone was tested for in vitro and in vivo genotoxic potential and was positive in the following assays: chromosomal aberrations and sister-chromatid exchanges in human lymphocytes, and micronuclei and sister-chromatid exchanges in mouse bone marrow.
reactions [see Coadministration of dexamethasone with drugs that are ocular symptoms or use corticosteroid-containing products for more than 6

in vitro. studies administration of corticosteroids to pregnant animals during discontinuation of therapy; therefore, in any situation of stress occurring migration, often accompanied by severe enterocolitis and potentially fatal Patients should be made aware that some infections viruses. myocardial infarction; therefore, therapy with HEMADY should be used with great

overload.
Neonatal hypoglycemia was also reported. years.Potentially severe psychiatric adverse reactions may with or without cleft palate), intrauterine growth restriction, and decreased His+ revertants.Published literature identified reduced testicular

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