in adult patients should be based on suspected or confirmed pathogen susceptibility as shown in Table 1 below. At these doses, plasma levels of imipenem antimicrobial activity decline to below 1 µg/mL or less in 4 to 6 hours. Deaths occurred between 6 and 88 minutes with doses of 771 to 1734 mg/kg.In the case of overdosage, discontinue PRIMAXIN I.V., treat symptomatically, and institute supportive measures as required. re-examined to determine whether it should be decreased or the antibiotic discontinued.As with other antibiotics, prolonged use of PRIMAXIN I.V. should only be used to treat bacterial infections. in MONOVIAL vials should be reconstituted using an appropriate diluent in an infusion bag, with a maximum port length of 14 mm.The MONOVIAL vial is not compatible with the ADD-Vantage diluent bags.The dry powder should be stored at a temperature below 25°C (77°F).Solutions of PRIMAXIN I.V. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and … The serum creatinine should represent a steady state of renal function. and probenecid results in increases in the plasma level and half-life of imipenem. However, PRIMAXIN I.V. 2 oral inhalations (180 mcg) 15 to 30 minutes before exercise. The MIC values obtained should be interpreted according to the following criteria:As with other susceptibility techniques, the use of laboratory control microorganisms is required. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.No dosage adjustment is required based on age (see PRIMAXIN I.V. If superinfection occurs during therapy, appropriate measures should be taken.Prescribing PRIMAXIN I.V. is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms in the conditions listed below:PRIMAXIN I.V. Its chemical name is sodium Imipenem and Cilastatin for Injection (I.V.) Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Its greatest affinity is for penicillin binding proteins (PBPs) 1A, 1B, 2, 4, 5 and 6 of Escherichia coli, and 1A, 1B, 2, 4 and 5 of Pseudomonas aeruginosa. Multiple dosing has no effect on the pharmacokinetics of either imipenem or cilastatin, and no accumulation of imipenem/cilastatin is observed.Imipenem, when administered alone, is metabolized in the kidneys by dehydropeptidase I resulting in relatively low levels in urine. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. A variety of bacterial and mammalian tests were performed to evaluate genetic toxicity. Therefore, it is not recommended that probenecid be given concomitantly with Imipenem and Cilastatin for Injection (I.V. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. at the 500-mg dose. possesses the characteristic low toxicity of the beta-lactam group of antibiotics, periodic assessment of organ system functions, including renal, hepatic, and hematopoietic, is advisable during prolonged therapy.Generalized seizures have been reported in patients who received ganciclovir and PRIMAXIN. 3514--250 mg imipenem equivalent and 250 mg cilastatin equivalent and 10 mg sodium bicarbonate as a bufferNo.
No overall differences in safety or effectiveness were observed between these subjects and younger subjects. is not recommended in pediatric patients with CNS infections because of the risk of seizures.Imipenem and Cilastatin for Injection (I.V.) Adult patients with impaired renal function, as judged by creatinine clearance
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