Hypothyroidism (sometimes severe) may be primary or subsequent to resolution of preceding amiodarone-induced hyperthyroidism; myxedema (may be fatal) has been reported. In December 1985, amiodarone was approved by the FDA for the treatment of arrhythmias.Amiodarone is available in oral and intravenous formulations. Patients with other risk factors (eg, older age, female sex, bradycardia, hypokalemia, hypomagnesemia, heart disease, and higher drug concentrations) are likely at greater risk for these toxicities.DOXOrubicin (Conventional): P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of DOXOrubicin (Conventional). It can be given by mouth, intravenously, or intraosseously. Management: Reduce the venetoclax dose by at least 50% in patients requiring concomitant treatment with P-glycoprotein (P-gp) inhibitors. Beta-blockers.

Management: In patients taking weak CYP3A4 inhibitors, the initial and second dose (given at least 2 hours later if needed) of ubrogepant should be limited to 50 mg.Vemurafenib: QT-prolonging Agents (Highest Risk) may enhance the QTc-prolonging effect of Vemurafenib. Clarithromycin: QT-prolonging Agents (Highest Risk) may enhance the QTc-prolonging effect of Clarithromycin. Amiodarone may increase the serum concentration of Vitamin K Antagonists. Because of the high iodine content of amiodarone, the thyroid gland is effectively saturated, thus preventing further uptake of isotopes of iodine. Triazolam: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Triazolam. Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade 1986; CDC 1984). Management: If this combination cannot be avoided, monitor for increased amiodarone serum concentrations and effects as well as for evidence of QT interval prolongation.Loratadine: Amiodarone may increase the serum concentration of Loratadine. Accumulation of amiodarone and DEA occurs in adipose tissue and highly perfused organs (i.e. It has a pH of 4.08. Corneal refractive laser surgery is generally contraindicated in amiodarone users (from manufacturers of surgical devices).• Photosensitivity: Avoid excessive exposure to sunlight; may cause photosensitivity.
It is used both in supraventricular arrhythmias and ventricular arrhythmias. If combined, monitor for QTc interval prolongation and ventricular arrhythmias. Carefully assess risk:benefit of coadministration of other drugs which may prolong QTc interval.• Warfarin: Use caution when initiating amiodarone in patients on warfarin. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring.Erdafitinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Erdafitinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Erythromycin (Systemic): Amiodarone may enhance the QTc-prolonging effect of Erythromycin (Systemic). Management: Consider alternatives to this combination. Amiodarone may increase the serum concentration of Beta-Blockers. The choice of dihydropyridine calcium-channel blocker depends on local recommendations. If combined, monitor for QTc interval prolongation and ventricular arrhythmias. Aprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Atazanavir: May increase the serum concentration of Amiodarone.AtorvaSTATin: Amiodarone may increase the serum concentration of AtorvaSTATin. Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Topotecan: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Topotecan.

Avoid concurrent treatment with amiodarone, or use with caution.

Patients with other risk factors (eg, older age, female sex, bradycardia, hypokalemia, hypomagnesemia, heart disease, and higher drug concentrations) are likely at greater risk for these toxicities.DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine.

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