just after rising from a recumbent or seated position. The diagnosis should be suspected Manufacturing Site. It … Dilatation of the coronary arteries also occurs. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, diethyl phthalate, hydrogenated castor oil, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, talc and titanium dioxide.ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90°C, and an optical rotation of +144° (2% in water, 20°C).Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane.For 60 mg and 120 mg: Meets USP Dissolution Test 1.The isosorbide mononitrate extended-release tablet is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate.The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins, especially the latter. In studies designed to detect effects of isosorbide mononitrate on embryo-fetal development, doses of up to 240 or 248 mg/kg/day, administered to pregnant rats and rabbits, were unassociated with evidence of such effects. humans. Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Copy the URL below and paste it into your RSS Reader application.

of such effects. and younger individuals (45–64 years) for the IMDUR 60 mg dose. of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Elderly patients may have reduced baroreceptor function and may develop severe orthostatic

Because animal reproduction studies are not always predictive of human response, isosorbide mononitrate extended-release tablets should be used during pregnancy only if clearly needed.Neonatal survival and development and incidence of stillbirths were adversely affected when pregnant rats were administered oral doses of 750 (but not 300) mg isosorbide mononitrate/kg/day during late gestation and lactation. 13668-106-05, Rarely, 240 mg may be required. The results of that study indicate that there are no significant differences in any of the pharmacokinetic variables of ISMN between elderly (≥65 years) and younger individuals (45 – 64 years) for the isosorbide mononitrate extended-release 60 mg dose.

At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. In industrial workers who have had long-term exposure to unknown (presumably high) doses of organic nitrates, tolerance clearly occurs.

isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting 13668-105-20, that might accelerate elimination of isosorbide mononitrate. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. to be unusually susceptible.Methemoglobin levels are available from most clinical laboratories. two age groups, however, were not statistically significant.

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