Our website services, content, and products are for informational purposes only. The study was stopped early when results showed that the drug was helping.Compared to people taking the placebo, those on the drug had a 34 percent lower risk of end-stage kidney disease, worsening kidney function, or death due to kidney problems.End-stage kidney disease included a need for dialysis or transplantation, or signs of kidney failure.People taking the drug also had a lower risk of cardiovascular death, heart attack, stroke, and hospitalization due to heart failure, compared to the placebo group.The new study found that this risk — along with the chance of bone fractures — was similar for the drug and placebo groups.However, the risk of diabetic ketoacidosis was higher in people taking the drug compared to those taking the placebo.
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Study authors for "Efficacy and Safety of Sitagliptin vs. Glipizide in Patients with Type 2 Diabetes and Moderate to Severe Chronic Renal Insufficiency" (abstract LB-PO3166) include Juan Arjona Ferreira, MD, Michel Marre, MD, PhD, George Bakris, MD, and Ton Rabelink, MD, PhD. Healthline Media does not provide medical advice, diagnosis, or treatment. Disclosures: Juan Arjona Ferreira is employed by and has ownership interest in Merck Sharp & Dohme, Corp. Michel Marre receives honoraria from is a scientific advisor for or has other relationships with Abbott, Eli Lilly, MSD, Novo Nordisk, Sanofi Aventis, and Servier. About The new study tested the drug canagliflozin, which is sold under the brand name Invokana, to see if it could lower the risk of kidney disease when used alongside standard treatments.Experts welcome this and other medications that target the complications of diabetes, but warn that high costs may limit wider access to these drugs.The study included 4,401 people, at least 30 years of age, with type 2 diabetes and chronic kidney disease. Healthline Media does not provide medical advice, diagnosis, or treatment. More research will be needed to determine if the drug can reduce the risk of kidney disease in these groups.The study was funded by the drug’s manufacturer, Janssen, a division of Johnson & Johnson. A new study reveals that a commonly prescribed drug for lowering blood sugar in patients with type 2 diabetes also lowers the risk of cardiovascular and kidney disease. Study co-author Prof. Vlado Perkovic, executive director of the George Institute of Global Health, weighs in on the findings: Prof. Neal comments on this, saying, “We don’t know why there was an increased risk of amputation, and further work is needed in this area. The study was stopped early when results showed that the drug was helping.Compared to people taking the placebo, those on the drug had a 34 percent lower risk of end-stage kidney disease, worsening kidney function, or death due to kidney problems.End-stage kidney disease included a need for dialysis or transplantation, or signs of kidney failure.People taking the drug also had a lower risk of cardiovascular death, heart attack, stroke, and hospitalization due to heart failure, compared to the placebo group.The new study found that this risk — along with the chance of bone fractures — was similar for the drug and placebo groups.However, the risk of diabetic ketoacidosis was higher in people taking the drug compared to those taking the placebo. Another major change from only a kidney friendly diet is emphasis on eating on a routine and balancing out your meals and snacks. All rights reserved. This life-threatening problem occurs in people with diabetes when the body breaks down fat too quickly, causing the blood to become acidic.The study didn’t include people with very advanced kidney disease or people with kidney disease due to conditions other than type 2 diabetes. Responsibility for the information and views expressed therein lies entirely with the author(s).
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