Domperidone may diminish the therapeutic effect of Monoamine Oxidase Inhibitors. This could result in serotonin syndrome. This could result in serotonin syndrome. Of particular concern is the development of hypertensive reactions when levodopa is used with nonselective MAOI.Levomethadone: May enhance the adverse/toxic effect of Monoamine Oxidase Inhibitors.Levonordefrin: Monoamine Oxidase Inhibitors may enhance the hypertensive effect of Levonordefrin. 0000010704 00000 n Serotonin syndrome generally doesn't cause any problems once serotonin levels are back to normal. 0000046662 00000 n Clin Infect Dis 2002 Jun 15;34(12):1651-2. St John's Wort may decrease the serum concentration of Serotonergic Agents (High Risk). When used for empiric therapy, give as part of an appropriate combination regimen (ATS/IDSA [Metlay 2019]; ATS/IDSA [Kalil 2016]; IDSA [Liu 2011]).Oral, IV: 600 mg every 12 hours. This could result in serotonin syndrome. Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined.Methadone: May enhance the serotonergic effect of Monoamine Oxidase Inhibitors. St John's Wort: May enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome.
This could result in serotonin syndrome. Protect from light and freezing. 75 0 obj <>stream
X��ccZ��330H22�o�r�T�T�`ª�(Θް�!�v�H�f!ƙ�����60`��P�3���A���AP�邔 Sc6sN���r�� �l81*2�f��`�@���,N+��Y��^��`��d�(l`k��q�u����Z��MX�����t��3 v bV��o��; �C2� Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. xref Anticholinergic toxicity; sepsis. Specifically, the risk for agranulocytosis and pancytopenia may be increasedDomperidone: Monoamine Oxidase Inhibitors may enhance the adverse/toxic effect of Domperidone. This could result in serotonin syndrome. Prior to administration mix gently by inverting bottle; do not shake. While linezolid and tedizolid may interact via this mechanism, management recommendations differ from other monoamine oxidase inhibitors. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics.Cladribine: May enhance the myelosuppressive effect of Myelosuppressive Agents.CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine.
Serotonergic Opioids (High Risk): Linezolid may enhance the serotonergic effect of Serotonergic Opioids (High Risk). 0000011718 00000 n However, linezolid clearly resembles the stronger monoamine oxidase inhibitors in its capacity to interact adversely with certain drugs. 0000015575 00000 n This could result in serotonin syndrome. Tryptophan: Linezolid may enhance the serotonergic effect of Tryptophan. Monitor for an exaggerated hypertensive response to dopamine.Droxidopa: Monoamine Oxidase Inhibitors may enhance the hypertensive effect of Droxidopa. endstream endobj 15 0 obj <> endobj 16 0 obj <>stream This could result in serotonin syndrome.Diphenoxylate: May enhance the hypertensive effect of Monoamine Oxidase Inhibitors.Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Existing MAOI therapy can result in paradoxical effects of added reserpine (e.g., excitation, hypertension). Some examples include aged or matured cheese, air-dried or cured meats (including sausages and salami), fava or broad bean pods, tap/draft beers, Marmite concentrate, sauerkraut, soy sauce, and other soybean condiments.Infusion: Store at 25°C (77°F). 0000188519 00000 n <<1B93D4F0BE52DA4E983A2212216D2295>]/Prev 193492>> However, limited data in the form of case reports in pediatric and adult patients suggest that linezolid may be useful in treating gram-positive CNS infections that have failed to respond to other treatment options describing successful treatment of documented VRE and • Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates.
Keep infusion bags in overwrap until ready for use.Oral suspension: Store at 25°C (77°F); following reconstitution store at room temperature and use suspension within 21 days. 0000003208 00000 n Oral suspension: Invert gently to mix prior to administration, do not shake.Some products may contain sodium and/or phenylalanine.
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