Monitor renal function periodically in patients receiving losartan and NSAID therapy.The antihypertensive effect of angiotensin II receptor antagonists, including losartan, may be attenuated by NSAIDs, including selective COX-2 inhibitors.The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Perform serial ultrasound examinations to assess the intra-amniotic environment. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.Safety and effectiveness of Losartan Potassium and Hydrochlorothiazide tablets in pediatric patients have not been established.In a controlled clinical study for the reduction in the combined risk of cardiovascular death, stroke and myocardial infarction in hypertensive patients with left ventricular hypertrophy, 2857 patients (62%) were 65 years and over, while 808 patients (18%) were 75 years and over.
AUC values for losartan, its active metabolite and hydrochlorothiazide, extrapolated from data obtained with losartan administered to rats at a dose of 50 mg/kg/day in combination with 12.5 mg/kg/day of hydrochlorothiazide, were approximately 6, 2, and 2 times greater than those achieved in humans with 100 mg of losartan in combination with 25 mg of hydrochlorothiazide. A meal slows absorption of Losartan and decreases its CThe volume of distribution of Losartan and the active metabolite is about 34 liters and 12 liters, respectively. There is no apparent rebound effect after abrupt withdrawal of Losartan. This is You may report side effects to Solco Healthcare US, LLC at 1-866-257-2597 or FDA at 1-800-FDA-1088.Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. The administration of toxic dosage levels in females (300/200 mg/kg/day) was associated with a significant (p<0.05) decrease in the number of corpora lutea/female, implants/female, and live fetuses/female at C-section. No overall differences in effectiveness were observed between these patients and younger patients. Evaluate the clinical response to Losartan Potassium and Hydrochlorothiazide tablets 50/12.5 and, if blood pressure remains uncontrolled after about 3 weeks of therapy, increase the dose to two tablets of Losartan Potassium and Hydrochlorothiazide tablets 50/12.5 once daily or one tablet of Losartan Potassium and Hydrochlorothiazide tablets 100/25 once daily.In patients whose blood pressure is not adequately controlled on 50 mg losartan potassium, initiate treatment with Losartan Potassium and Hydrochlorothiazide tablets 50/12.5. If symptomatic hypotension should occur, supportive treatment should be instituted.Neither Losartan nor its active metabolite can be removed by hemodialysis.Losartan potassium is an angiotensin II receptor blocker acting on the ATLosartan potassium, USP is white to off-white powder with a molecular weight of 461.01. Fluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40%, but increased the AUC of Losartan by approximately 70% following multiple doses. Subgroup analyses can be difficult to interpret and it is not known whether these represent true differences or chance effects.Losartan Potassium Tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side and are supplied as follows:Losartan Potassium Tablets USP, 50 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z16" on one side and lip type breakline on other side and are supplied as follows:Losartan Potassium Tablets USP, 100 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z18" on one side and plain on other side and are supplied as follows:NDC 68382-137-77 in cartons of 100 tablets (10 x 10 unit-dose)Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. With the exception of neonatal weight gain (which was affected at doses as low as 10 mg/kg/day), doses associated with these effects exceeded 25 mg/kg/day (approximately three times the maximum recommended human dose of 100 mg on a mg/mIt is not known whether Losartan is excreted in human milk, but significant levels of Losartan and its active metabolite were shown to be present in rat milk. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.Coadministration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia.
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