Find information on medicines by active ingredient or brand nameThe more medicines you take, the more difficult it can be to remember important information about them.An independent peer-reviewed journal providing critical commentary on drugs and therapeutics.Timely, independent, evidence-based information on new drugs and medical tests, and changes to the PBS and MBS.Find information on medicines by active ingredient or brand nameInformation for consumers on prescription, over-the-counter and complementary medicines.Provides consumers with a way to report and discuss adverse experiences with medicinesKeep track of medicines and access important health info any time and anywhere, especially in emergencies.Find information on medicines by active ingredient or brand nameIndependent peer-reviewed journal providing critical commentary on drugs and therapeutics for health professionalsProvides health professionals with timely, independent and evidence-based informationFind information on medicines by active ingredient or brand nameUp-to-date, evidence-based information about safe and wise use of biological disease-modifying antirheumatic drugs (bDMARDs) and other specialised medicines.Improving clinical practice and health outcomes for Australia.Provides health professionals with timely, independent and evidence-based informationOngoing education for Aboriginal and Torres Strait Islander health workers and practitioners on quality use of medicines and medical testsPractical information, tools and resources for health professionals and staff to help improve the quality of health care and safety for patientsRelevant, timely and evidence-based information for Australian health professionals and consumers.Find information on medicines by active ingredient or brand name20 years of helping Australians make better decisions about medicines, medical tests and other health technologiesFind information on medicines by active ingredient or brand nameOn 1 October and 1 December 2019, changes were made to the listings of all oral mesalazine medicines on the PBS General Schedule (Section 85) for the treatment of either ulcerative colitis alone or ulcerative colitis/Crohn disease.In the new listings, the restriction levels have been decreased to Restricted Benefit and the clinical criteria have been removed for all PBS-listed oral mesalazine medicines (Table 1).At the March 2019 PBAC meeting, the PBAC considered a literature review, feedback from sponsors and utilisation analysis of oral 5-aminosalicylic acids (5-ASA) medicines (balsalazide, mesalazine, olsalazine and sulfasalazine).The PBAC found that a high proportion of patients (over 50%) are being prescribed mesalazine as first-line treatment, despite the PBS restrictions of hypersensitivity to a sulfonamide or intolerance to sulfasalazine, and that the daily dose of mesalazine had increased since it was initially PBS-listed.

The PBAC concluded that subsidised use of oral mesalazine was no longer cost-effective.The DUSC reports found that tolerance and safety issues for sulfasalazine were likely driving the greater use of mesalazine.The PBAC also considered that oral mesalazine may be used preferentially over sulfasalazine due to improved tolerance, reduced monitoring requirements (less frequent renal and liver function testing, and no need for complete blood countsThe PBAC advised it was willing to decrease the restriction levels to allow oral mesalazine to be used in the same circumstances as sulfasalazine. Mesalazine is also available as enemas or suppositories – these are described in separate leaflets available on the website.. The average small bowel transit time is approximately 3-4 hours in healthy volunteers.

This leaflet has been written specifically about the use of this medicine in children.

24 Jun 2020

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