First, it included only randomized trials of which a large number were of high quality and had large sample sizes. Missing standard deviations were calculated by multiplying standard errors of means by the square root of the sample size: s.d. × √Out of 43 clinical trials that were primarily identified as assessing zinc supplementation in patients with acute diarrhoea, 18 of themEighteen studies that met the inclusion criteria recruited a total of 11 180 participants (6109 assigned to the experimental group and 5071 assigned to the control group) younger than 5 years of age with acute diarrhoea.

Antimicrobial therapy can also lead to adverse events, and unnecessary treatments add to resistance development. Despite an improvement in diagnostic and treatment approaches, morbidity and mortality due to acute diarrhoea are significant among children younger than 5 years of age, especially those in developing countries.Most cases of AGE are self‐limited and do not require antimicrobial therapy. Possible mechanisms for the beneficial antidiarrhoeal effect of zinc are discussed in more detail elsewhere.Numerous clinical trials and two subsequent meta‐analysesThis review was initiated as part of the development of the European guidelines for the management of AGE in childrenOnly randomized controlled trials (RCTs) that evaluated the effectiveness of zinc in the treatment of AGE in children were included.

9. Secretory state regulates Zn

2+
The management and therapy of acute gastroenteritis will be discussed in two epidemiological settings: community-acquired diarrhoea, and travellers' diarrhoea.

We found no significant reduction in stool frequency and stool output in the zinc‐supplemented group compared with the placebo group. One of the dilemmas in assessing patients with acute diarrhoea is deciding when to test for aetiological agents and when to initiate antimicrobial therapy. All studies were performed in children up to 5 years of age with AGE. The weighted mean difference (WMD) between the treatment and control groups was selected to represent the difference in continuous outcomes. Patients received zinc at any dose and in any form or placebo/no intervention as an adjunct to the treatment of diarrhoea. Merrick N, Davidson B, Fox S. Treatment of acute gastroenteritis: too much and too little care.



Nevertheless, empirical antimicrobial therapy can be necessary in certain situations, such as patients with febrile diarrhoeal illness, with fever and bloody diarrhoea, symptoms persisting for >1 week, or immunocompromised status.We use cookies to help provide and enhance our service and tailor content and ads. When to … Oral rehydration, maintenance, and nutritional therapyWater and Sanitation‐Related Diseases and the Changing Environment, Dietary vs. pharmacological doses of zinc: A clinical review, Akut viral gastroenteritlerde oral çinko kullanımının hastalığın semptomları ve süresine etkisinin değerlendirilmesi, Comparison of Baseline Serum Zinc Level in 1 - 5-Year-Old Children Hospitalized for Gastroenteritis with Children Hospitalized for Other Diseases at Dr. Mohammad Kermanshahi Hospital in Kermanshah, Journal of Kermanshah University of Medical Sciences, Causes of impaired oral vaccine efficacy in developing countries, Gastroenteritis: An overview of the symptoms, transmission and management, Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition, Comparison of Recommendations in Clinical Practice Guidelines for Acute Gastroenteritis in Children, Journal of Pediatric Gastroenterology and Nutrition, Zinc supplementation in young children: A review of the literature focusing on diarrhoea prevention and treatment, Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition, Cost-Effectiveness Analysis of Zinc Supplementation for Treatment of Acute Diarrhea in Children Younger Than 5 Years in Colombia, Journal of Pediatric Gastroenterology and Nutrition, Zinc supplementation fails to increase the immunogenicity of oral poliovirus vaccine: A randomized controlled trial, Crosstalk between Zinc Status and Giardia Infection: A New Approach, The Potential for Zinc Stable Isotope Techniques and Modelling to Determine Optimal Zinc Supplementation, A Double Blind Randomized Trial Showing Probiotics to be Ineffective in Acute Diarrhea in Indonesian Children, Oral zinc supplements are ineffective for treating acute dehydrating diarrhoea in 5–12‐year‐olds, A Question Mark on Zinc Deficiency in 185 Million People in Pakistan—Possible Way Out, Zinc and copper supplementation are not cost-effective interventions in the treatment of acute diarrhea, A study to evaluate the acceptability, feasibility and impact of packaged interventions (“Diarrhea Pack”) for prevention and treatment of childhood diarrhea in rural Pakistan, No association of LCT-13910 single nucleotide polymorphism with gastroenteritis in Korean children, Hospital management of children with acute gastroenteritis, Practical Approach to Paediatric Gastroenterology, Hepatology and Nutrition, Review article: the management of acute gastroenteritis in children, Zinc supplementation in intensive care: Results of a UK survey, The management of acute diarrhea in children in developed and developing areas: from evidence base to clinical practice, Roles of Zinc in the Pathophysiology of Acute Diarrhea, ORS Containing Zinc Does Not Reduce Duration or Stool Volume of Acute Diarrhea in Hospitalized Children, Journal of Pediatric Gastroenterology and Nutrition, Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis, Eusorbents and Eusorption: A Review of Physiological Events to Therapeutic Concepts, Efficacy of a New Hypotonic Oral Rehydration Solution Containing Zinc and Prebiotics in the Treatment of Childhood Acute Diarrhea: A Randomized Controlled Trial, Inhibitory Effect of Zinc on the Absorption of JBP485 via the Gastrointestinal Oligopeptide Transporter (PEPT1) in Rats, Zinc Intervention Strategies: Costs and Health Benefits, Nutrients, Dietary Supplements, and Nutriceuticals, Water and Sanitation‐Related Diseases and the Environment, Oral Zinc for the Treatment of Acute Gastroenteritis in Polish Children: A Randomized, Double-Blind, Placebo-Controlled Trial, Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism, Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes,
Acute gastroenteritis (AGE) remains one of the most common diseases in childhood. Gastroenteritis Treatment Share on Facebook Share on Twitter Share on Pinterest Email Print In this Article Call 911 if: Know the Signs of an Emergency: 1.

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