risk of torsades de pointes feldene

organization.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)Sudden cardiac death in the united states, 1989 to 1998Postmortem molecular screening in unexplained sudden deathPostmortem long QT syndrome genetic testing for sudden unexplained death in the youngProlonged QTc interval and risk of sudden cardiac death in a population of older adultsQTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrestThe association between the length of the QT interval and mortality in the cardiovascular health studyQTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetesHeart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC studyTorsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patientsExaggerated QT prolongation after cardioversion of atrial fibrillationNon-cardiac QTc-prolonging drugs and the risk of sudden cardiac deathFemale gender as a risk factor for torsades de pointes associated with cardiovascular drugsNontranscriptional regulation of cardiac repolarization currents by testosteroneTestosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbitsProgesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling studyDrug-induced long QT syndrome in women: review of current evidence and remaining gapsDiuretic therapy for hypertension and the risk of primary cardiac arrestA new oral therapy for long QT syndrome: long-term oral potassium improves repolarization in patients with HERG mutationsNormalization of acquired QT prolongation in humans by intravenous potassiumEplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failureRisk factors and predictors of torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving dofetilideDofetilide in patients with congestive heart failure and left ventricular dysfunction: Danish Investigations of Arrhythmia and Mortality on Dofetilide Study GroupDeterminants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death StudyRisk factors and predictors of torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving dofetilideIncreased mortality after dronedarone therapy for severe heart failureMortality and morbidity in patients receiving encainide, flecainide, or placeboAntipsychotics and the risk of sudden cardiac deathQTc-prolonging drugs and hospitalizations for cardiac arrhythmiasAnti-HERG activity and the risk of drug-induced arrhythmias and sudden deathUpdate on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug developmentEvaluation of ventricular arrhythmias in early clinical pharmacology trials and potential consequences for later developmentRisk of torsades de pointes with non-cardiac drugs: doctors need to be aware that many drugs can cause QT prolongationRegistry for torsades de pointes with drug treatment existsChronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndromeChronic amiodarone reduces transmural dispersion of repolarization in the canine heartAugmentation of late sodium current unmasks the proarrhythmic effects of amiodaroneEffects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trialEffect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trialElectrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic propertiesTaking the “idio” out of “idiosyncratic”: predicting torsades de pointesLong QT syndrome: reduced repolarization reserve and the genetic linkTransmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesiaSodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de pointes in models of acquired and congenital long QT syndromeCharacteristics and distribution of m cells in arterially perfused canine left ventricular wedge preparationsCellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndromeTpeak-Tend interval as an index of transmural dispersion of repolarizationUnique topographical distribution of m cells underlies reentrant mechanism of torsade de pointes in the long-QT syndromeElectrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patternsEffect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersionTpeak-Tend interval as an index of global dispersion of ventricular repolarization: evaluations using monophasic action potential mapping of the epi- and endocardium in swineIn vivo validation of the coincidence of the peak and end of the T wave with full repolarization of the epicardium and endocardium in swineComputer aided development of antiarrhythmic agents with class IIIa propertiesInstability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmicPhase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmiaDetection of proarrhythmia in the female rabbit heart: blinded validationBlinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instabilityQT and TdP: QT: an unreliable predictor of proarrhythmiaUse and abuse of QT and triad in cardiac safety research: importance of study design and conductRefining detection of drug-induced proarrhythmia: QT interval and triadPhase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: direct evidence from intracellular recordings in the intact left ventricular wallIn vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongationPatient-specific induced pluripotent stem-cell models for long-QT syndromeModelling the long QT syndrome with induced pluripotent stem cellsUsing induced pluripotent stem cells to investigate cardiac phenotypes in timothy syndromeDiagnostic criteria for the long QT syndrome: an updateRisk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndromeProlonged QTc interval and risk of sudden cardiac death in a population of older adultsQTc dispersion predicts cardiac mortality in the elderly: the Rotterdam StudyQT dispersion, QT maximum and risk of cardiac death in the Caerphilly Heart StudyQT dispersion as a predictor of long-term mortality in patients with acute myocardial infarction and clinical evidence of heart failureDrug-induced QT dispersion: does it predict the risk of torsade de pointes?The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heartMicrovolt T-wave alternans: physiological basis, methods of measurement, and clinical utility: consensus guideline by International Society for Holter and Noninvasive ElectrocardiologyT wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicityT-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersionThe morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmiasTransmural dispersion of repolarization and ventricular tachyarrhythmiasRepolarization characteristics and incidence of torsades de pointes in patients with acquired complete atrioventricular blockIncreased short-term variability of repolarization predicts D-sotalol-induced torsades de pointes in dogsBeat-to-beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointesBeat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot studyLow penetrance in the long-QT syndrome: clinical impactA sodium-channel mutation causes isolated cardiac conduction diseaseFour potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in FinlandHigh prevalence of four long QT syndrome founder mutations in the Finnish populationGenetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practiceFurther evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointesEpinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndromeEpinephrine QT stress testing in the evaluation of congenital long-QT syndrome: diagnostic accuracy of the paradoxical QT responseI(kr) channel blockade to unmask occult congenital long QT syndromeAllelic variants in long-QT disease genes in patients with drug-associated torsades de pointesVariant of SCN5A sodium channel implicated in risk of cardiac arrhythmiaRole of SCN5A Y1102 polymorphism in sudden cardiac death in blacksSNP S1103Y in the cardiac sodium channel gene SCN5A is associated with cardiac arrhythmias and sudden death in a white familyCommon variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA studyA common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarizationAssociation of NOS1AP genetic variants with QT interval duration in families from the diabetes heart studyCommon NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam studyAssociations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order AmishCommon variants at ten loci modulate the QT interval duration in the QTSCD studyCommon variants at ten loci influence QT interval duration in the QTGEN studyKCNH2–K897T is a genetic modifier of latent congenital long-QT syndromeNOS1AP is a genetic modifier of the long-QT syndromePolymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndromeA common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant deathD85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndromeRelationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parametersGenetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populationsGenetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam StudyA large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes

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