Despite these concerns, there are few recent systematic reviews comparing the impact on child developmental outcomes for individual mood-stabilizing agents to inform clinical decisions. The most consistent finding was a dose–response relationship for valproate with higher doses associated with poorer global cognitive abilities compared to other antiepileptic drugs. Second, high-dose valproate has been consistently associated with poorer neurodevelopmental outcomes with available data suggesting that lamotrigine may be a preferred treatment to valproate or carbamazepine due to lower risk of adverse outcomes for the child, but further exploration is required to confirm this. This was due to small study size, retrospective design and neither of the studies adjusted for confounding variables or used blinding of child assessments.Strong aspects of the SGA studies include prospective study design and use of blinding in two of the three identified studies. Additionally, while the reference lists of all included articles were examined, there was no extensive search of the grey literature beyond that.

The SGA studies found an early transient neurodevelopmental delay at 2 and 6 months, with lower mean adaptive behaviour scores for those exposed to clozapine compared to other SGAs, although reassuringly by 12 months of age there was no statistically significant difference between groups. You can be signed in via any or all of the methods shown below at the same time.The email address and/or password entered does not match our records, please check and try again. This included half of the studies having a prospective design, decreasing the potential for recall bias surrounding teratogen use and confounding variables. These studies are summarized in Three studies were identified, including a prospective cohort study with controls, a prospective case control and a prospective cohort which was a post hoc analysis of the case-control study. The next most reliable measurement is prospective medical records. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website.Pregnancy and neurodevelopmental outcomes with in-utero antiepileptic agent exposure. This rare mental illness is related…Experts divide the types of cognitive impairment into four categories: mild intellectual disability, moderate intellectual disability, severe intellectual disability, and profound intellectual…Depression quotes and sayings about depression can provide insight into what it's like living with depression as well as inspiration and a feeling of "someone gets it." The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent.Create a link to share a read only version of this article with your colleagues and friends. the site you are agreeing to our use of cookies. This site uses cookies. First, each mood-stabilizing agent has a different risk–benefit profile for impact on cognitive development. Never stop taking bipolar medication without medical guidance.Although there are many things we don’t know about the safety of mood stabilizers during pregnancy, there are certain facts to consider.If you are being treated for bipolar disorder and are pregnant, trying to conceive or breastfeeding, you should check with your doctor about the risks and benefits of taking mood stabilizers in pregnancy.Schizoaffective disorder is, like schizophrenia, a psychotic disorder. These are summarized in Infants exposed to antipsychotics showed significantly lower INFANIB scores compared to unexposed infants, after controlling for significant co-variants using multiple regression analysis. In all, 1163 articles were excluded based on title and then a further 437 articles were excluded based on review of abstract. However, one of the key questions for women and clinicians during pregnancy is whether there are implications of exposure to mood stabilizers for longer term child development. This is a process which requires careful and thoughtful consideration, weighing the risk of adverse outcomes associated with exposure to a particular drug against the risk of recurrent illness in the setting of medication discontinuation.

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