COVID-19 is an emerging, rapidly evolving situation. Beta-blockers may be given in extreme cases but not if the patient is asthmatic. The drug is also given to patients with chronic respiratory failure. A comparison of low dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. Although large variability in theophylline elimination occurs, individual patient variability is usually relatively small in the absence of confounding factors such as drug interactions. Caffeine therapy in neonates. Drugs used in the treatment of asthma: the methylxanthines, cromolyn sodium, and other agents. Measure the plasma potassium concentration urgently, repeat frequently and correct hypokalaemia. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard Theophylline has a low therapeutic index. Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease Theophylline has a low therapeutic index. http://www.pharmacytimes.com/top200..Goodman DC, Littenberg B, O’Conner GT, Brooks JG. Taylor & Francis Continue typing to refine. After a fast of at least 10 hours, thirty healthy, non-smoking, non-obese, non-pregnant adult volunteers between the ages of 18 and 45 will be given one dose of 300mg (80mg/15ml concentrate) theophylline (theophylline elixir) on Day 1.

4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Colchicine has a narrow therapeutic index and is extremely toxic in overdose. This may be titrated to either 300 mg or 400 mg dependent on the therapeutic response. The effects on respiration can be assessed through peak lung flow and other lung function tests that provide i… Smoking and alcohol consumption can also increase clearance of theophylline.The following reduce clearance and a reduced dosage may therefore be necessary to avoid side-effects: aciclovir, allopurinol, carbimazole, cimetidine, clarithromycin, diltiazem, disulfiram, erythromycin, fluconazole, interferon, isoniazid, methotrexate, mexiletine, nizatidine, pentoxifylline, propafenone, propranolol, thiabendazole, verapamil and oral contraceptives (see section 4.9). Do not exceed 20 micrograms/ml.Theophylline is distributed through all body compartments; approximately 60% is bound to plasma proteins.An effective plasma concentration is considered to be 5-12 micrograms/ml, although plasma concentrations up to 20 micrograms/ml may be necessary to achieve efficacy in some cases. The fatal dose may be as little as 4.5 g in an adult (60 mg/kg in a child), but is generally higher.Warning: Serious symptoms may develop as long as 12 hours after overdosage with prolonged release formulations.Alimentary symptoms: Nausea, vomiting (which is often severe), epigastric pain and haematemesis.
The objective of this study was to assess the impact of multiple doses of terbinafine on single-dose theophylline pharmacokinetic parameters in an open-label, randomized, crossover study. DiGiulio G, Hercsmar C, Krug S, Alpert S, Marx C. Hospital treatment of asthma: lack of benefit from theophylline given in addition to nebulized albuterol and intravenously administered corticosteroid.

Monitoring is usually performed only on those patients who are unresponsive to high doses of caffeine or who have signs of toxicity.Monitoring should be performed on those patients who are unresponsive to therapy, as judged by clinical symptoms such as reduction in episodes of apnea, in the presence of high doses of caffeine. Therefore, theophylline should be considered to have the potential for developmental toxicity in humans.Blister packs consisting of aluminium foil sealed to 250 µm PVC with a PVdC coating of at least 40 gsm thickness, containing 56 tablets.® UNIPHYLLIN, CONTINUS, NAPP and the Napp device (logo) are registered Trade Marks.Cambridge Science Park, Milton Road, Cambridge, Cambridgeshire, CB4 0GWTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in.

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