The safety margin for this effect is not known.Store in the original package in order to protect from moisture.Tegretol 100mg come in PVC/PE/PVDC blister packs of 84 and 100 tablets.Tegretol 200mg come in PVC/PE/PVDC blister packs of 84 and 100 tablets.Tegretol 400mg come in PVC/PE/PVDC blister packs of 56.2nd Floor, The WestWorks Building, White City Place, 195 Wood Lane, London, W12 7FQTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Fosphenytoin is a parenteral prodrug of phenytoin that is more tolerable than parenteral phenytoin.Newer antiepileptic drugs may control seizures more effectively, but their significant potential for serious side effects requires a thorough knowledge of the drugs and careful consideration of the risks and benefits.Gabapentin (Neurontin) has been approved as adjunctive therapy in adults with partial seizures with or without secondary generalization Adjunctive therapy for partial seizures with or without secondary generalizationBegin with 300 mg daily; increase to 900 to 1,800 mg daily given every 6 to 8 hoursSomnolence, fatigue, ataxia, dizziness, gastrointestinal upset, dyspneaAdjunctive therapy for partial seizures with or without secondary generalizationBegin with 50 mg daily; increase to 300 to 500 mg daily given every 12 hours; for concomitant use with valproic acid (Depakene): begin with 25 mg every other day; increase to 150 mg daily given every 12 hoursRash, including life-threatening rashes, dizziness, ataxia, blurred vision, nauseaAdjunctive therapy or monotherapy in adults when seizures are so severe as to warrant use despite risk of aplastic anemia or hepatic failure; in children with Lennox-Gastaut syndrome when seizures are not controlledAdults: begin with 1,200 mg daily given every 6 to 8 hours400-mg and 600-mg scored tablets; 600 mg per 5-mL suspensionAnorexia, vomiting, insomnia, somnolence, aplastic anemia, hepatotoxicityChildren: 15 to 45 mg per kg per day given every 6 to 8 hoursBegin with 50 mg daily; increase to 50 to 400 mg daily given every 12 hoursDizziness, somnolence, ataxia, confusion, fatigue, paresthesias, speech difficulities, diplopia, impaired concentration and nauseaStatus epilepticus; parenteral maintenance of phenytoin levels; parenteral treatment and/or prevention of seizuresPruritus, nystagmus, dizziness, somnolence, ataxia, nausea, tinnitus, hypotension, and groin discomfort with infusionFor nonemergent therapy: 15 to 30 mg per kg IV or IM, followed by 6 to 12 mg per kg IV or IM for maintenance therapyAdjunctive therapy for partial seizures with or without secondary generalizationBegin with 300 mg daily; increase to 900 to 1,800 mg daily given every 6 to 8 hoursSomnolence, fatigue, ataxia, dizziness, gastrointestinal upset, dyspneaAdjunctive therapy for partial seizures with or without secondary generalizationBegin with 50 mg daily; increase to 300 to 500 mg daily given every 12 hours; for concomitant use with valproic acid (Depakene): begin with 25 mg every other day; increase to 150 mg daily given every 12 hoursRash, including life-threatening rashes, dizziness, ataxia, blurred vision, nauseaAdjunctive therapy or monotherapy in adults when seizures are so severe as to warrant use despite risk of aplastic anemia or hepatic failure; in children with Lennox-Gastaut syndrome when seizures are not controlledAdults: begin with 1,200 mg daily given every 6 to 8 hours400-mg and 600-mg scored tablets; 600 mg per 5-mL suspensionAnorexia, vomiting, insomnia, somnolence, aplastic anemia, hepatotoxicityChildren: 15 to 45 mg per kg per day given every 6 to 8 hoursBegin with 50 mg daily; increase to 50 to 400 mg daily given every 12 hoursDizziness, somnolence, ataxia, confusion, fatigue, paresthesias, speech difficulities, diplopia, impaired concentration and nauseaStatus epilepticus; parenteral maintenance of phenytoin levels; parenteral treatment and/or prevention of seizuresPruritus, nystagmus, dizziness, somnolence, ataxia, nausea, tinnitus, hypotension, and groin discomfort with infusionFor nonemergent therapy: 15 to 30 mg per kg IV or IM, followed by 6 to 12 mg per kg IV or IM for maintenance therapyGabapentin is well absorbed orally, circulates mostly unbound in the plasma and is excreted unchanged in the kidneys without appreciable metabolism in the body.
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