Abdominal pain, agitation, aggression, cholecystitis, convulsions, heart block (all types), hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, rhabdomyolysis, QTc prolongation, Stevens Johnson syndrome toxic epidermal necrolysis and torsade de pointesHypersensitivity to donepezil or to piperidine derivativesRisk of GI bleed, especially in patients with history of gastric ulcer or those on NSAIDsCholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesiaCholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart blockCan cause vomiting (higher risk with dose of 23 mg/day)May cause anorexia and/or weight loss (dose dependent)Cholinomimetics may cause bladder outflow obstructionsCholinomimetics are believed to have some potential to cause generalized convulsionsCholinesterase inhibitors should be prescribed with care with history of asthma or obstructive pulmonary diseaseUse with caution in patients with history of seizure disorders, urinary tract obstruction, peptic ulcer disease, cardiac conduction abnormalities, or respiratory disease including COPD or asthmaMay be associated with QT prolongation and torsades de pointes; use caution in patients at risk of cardiac repolarizationRare cases of neuroleptic malignant syndrome reported; may consider discontinuing therapy if symptoms occurRare cases of rhabdomyolysis reported following few months of therapy or following therapy initiation; use caution in patients with risk factors rhabdomyolysis, including medications associated with rhabdomyolysis; consider discontinuing therapy if marked elevation of CPK levels or symptoms suggesting rhabdomyolysis occurLow weight patients <55 kg may experience more weight loss, nausea, and vomiting than patients >55 kgThere are no adequate data on developmental risks associated with use in pregnant womenThere are no data on presence of donepezil or metabolites in human milk, effects on breastfed infant, or on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal conditionA: Generally acceptable. This reaction, which is proportional to the dosage of both Disulfiram and alcohol, will persist as long as alcohol is being metabolized.

In addition, a complete blood count and serum chemistries, including liver function tests, should be monitored.Patients taking Disulfiram tablets should not be exposed to ethylene dibromide or its vapors.

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Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.OPTIC NEURITIS, PERIPHERAL NEURITIS, POLYNEURITIS, AND PERIPHERAL NEUROPATHY MAY OCCUR FOLLOWING ADMINISTRATION OF Disulfiram.Multiple cases of hepatitis, including both cholestatic and fulminant hepatitis, as well as hepatic failure resulting in transplantation or death, have been reported with administration of Disulfiram.Occasional skin eruptions are, as a rule, readily controlled by concomitant administration of an antihistaminic drug.In a small number of patients, a transient mild drowsiness, fatigability, impotence, headache, acneform eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste may be experienced during the first two weeks of therapy.

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