0000048885 00000 n Therefore, the use of 0000145383 00000 n startxref 0000017116 00000 n doi: 10.2165/00003495-199039060-00006. 0000105865 00000 n Fluconazole standard stock solution was prepared by dissolving 125 mg of standard accurately weighted in 100 mL volumetric flask. Fluconazole is a bis-triazole antifungal drug with novel pharmacokinetic properties (metabolic stability, relatively high water solubility) which contribute to its therapeutic activity. Fluconazole is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. fluconazole in lactating mothers is not recommended.Fluconazole has also rarely been associated with severe or lethal Some people are allergic to azoles, so those allergic to other azole drugs might be allergic to fluconazole.Fluconazole taken at low doses is in FDA pregnancy category C. However, high doses have been associated with a rare and distinct set of birth defects in infants. 0000143536 00000 n Since CLOT is a lipophilic drug (Log K o/w = 4.1) with low aqueous solubility (solubility=0.49 mg/l)[7,8] and slow dissolution in water[], its slow release from suppository formulations may be anticipated. This includes candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. doi: 10.2165/00003495-199039060-00006. • The vapor pressure and sublimation thermodynamics were determined. Clinical improvement has been reported in a few cases of pulmonary Aspergillus infection but the overall efficacy of conventional dosages of fluconazole in this mycosis has not been as impressive. 0000005170 00000 n
Comparative trials of maintenance therapy indicate a similar low rate of relapse among patients given oral fluconazole once daily and intravenous amphotericin B once weekly. 1990 Sep;24(9):860-7. doi: 10.1177/106002809002400914.Drugs. Clipboard, Search History, and several other advanced features are temporarily unavailable. 0000017304 00000 n 0000160873 00000 n
The solubility of fluconazole in these solvents is approximately 20, 33, and 16 mg/ml, respectively.
0000142845 00000 n 0000145946 00000 n Print 2017 Aug.Jundishapur J Microbiol. 0000002119 00000 n Ketoconazole is insoluble in water, so I have my doubts about its solubility in saline solution. In patients with oropharyngeal or oesophageal candidiasis, fluconazole produces rapid relief and eradicates the yeast in 50 to 90% of patients. xref Clinical experience is limited to a relatively small number of mycoses and, as might be expected at this early stage of development, optimal dosage and duration of treatment for some serious mycoses is not yet established. It was kept in ultrasonic bath for 30min, and the volume was making up to volume with water. 0000016857 00000 n Each mL contains 2 mg of fluconazole and 9 mg of sodium chloride or 56 mg of dextrose, hydrous. 0000160274 00000 n 0000089993 00000 n A single oral dose of fluconazole was comparable to standard topical azole therapy in women with acute vaginal candidiasis. 0000030281 00000 n 0000011471 00000 n Capsules contain lactose and should not be given to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Following oral dosing, fluconazole is almost completely absorbed within two hours.In a bulk powder form, it appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol.InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2Pfizer Australia Pty Ltd. Diflucan (Australian Approved Product Information). Fluconazole is a bis-triazole antifungal drug with novel pharmacokinetic properties (metabolic stability, relatively high water solubility) which contribute to its therapeutic activity.
0000161104 00000 n doi: 10.1128/AAC.00791-17. Name must be less than 100 characters Unable to load your delegates due to an error
• The melting temperature and enthalpy of fluconazole were obtained. The fluconazole MIC against one C. glabrata strain did increase by two dilutions when dissolved in water compared to DMSO (8 μg/ml versus 2 μg/ml, respectively). The limit is 0.002%. 0000143994 00000 n 142 0 obj <>stream 0000028366 00000 n 0000160531 00000 n 0000049136 00000 n 0000005306 00000 n The Fluconazole has sufficient solubility in all medias (0.1N HCl (pH1.2), pH 4.5 acetate buffer, pH 6.8 phosphate buffer), therefore surfactants are not needed.
Springer 75 68 2009;69(3):361-92. doi: 10.2165/00003495-200969030-00010.J Fungi (Basel). Fluconazole is an antifungal agent. 0000012769 00000 n 0000009256 00000 n
Dissolve in 5 mL of alcohol, add 5 mL of distilled water, and mix. 0000017775 00000 n 0000028633 00000 n 0000010543 00000 n 0000003354 00000 n DIFLUCAN Tablets contain 50 mg, 100 mg, 150 mg, or 200 mg of fluconazole and the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&C Red No.
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