It is slightly soluble in water and sparingly soluble in ethanol. 2008 Sep;13(3):311-9. doi: 10.1007/s10741-007-9077-3. 2015 Jun 1;8(2):9-19. doi: 10.5539/gjhs.v8n2p9.Curr Ther Res Clin Exp. The median daily dose was 5 mg (range, 1.25-15 mg) in both the fixed-dose and dose-titration groups. Epub 2008 Jan 3.Fournie-Zaluski MC, Fassot C, Valentin B, Djordjijevic D, Reaux-Le Goazigo A, Corvol P, Roques BP, Llorens-Cortes C.Proc Natl Acad Sci U S A. Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding amlodipine besylate tablets to other antihypertensive therapy. [29090] [64409] In a study of 31 lactating women with pregnancy-induced hypertension, the median relative infant dose (RID) of amlodipine in human milk was 4.2% (interquartile range, 3.12% to 7.25%) and the maximum RID was 15.2%. Your doctor will tell you which of these are most important for you. 2015 Aug 26;2015(8):CD007449. There is no information on the effect of amlodipine on milk production in breast-feeding women. Please confirm that you would like to log out of Medscape. Elsevier Science Dosage Modifications Renal impairment. It's usual to take amlodipine once a day.

If you log out, you will be required to enter your username and password the next time you visit. Dose equivalence and conversion Tablets from various suppliers may contain different salts (e.g. Indicated for hypertension, to lower blood pressureLowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions5 mg/day PO initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day maintenance: 5-10 mg/dayTreatment of chronic stable angina, vasospastic angina (Prinzmetal or variant angina), and angiographically documented CAD in patients without heart failure or EF <40%5-10 mg/day PO initially; maintenance: 10 mg/day POStart dosing at low end of dosing range; elderly patients have greater frequency of decreased renal, hepatic or cardiac function2.5-5 mg/day PO initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day PO; maintenance: 5-10 mg/day POTreatment of chronic stable angina, vasospastic angina (Prinzmetal or variant angina), and angiographically documented CAD in patients without heart failure or EF <40%2.5-10 mg/day PO initially; maintenance: 10 mg/day POCardiovascular: Arrhythmia (eg, ventricular tachycardia, atrial fibrillation), bradycardia, chest pain, peripheral ischemia, syncope, tachycardia, vasculitisCentral and peripheral nervous system: Hypoesthesia, neuropathy peripheral, paresthesia, tremor, vertigoGastrointestinal: Anorexia, constipation, dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasiaGeneral: Allergic reaction, asthenia, back pain, hot flushes, malaise, pain, rigors, weight gain, weight decreaseMusculoskeletal system: Arthralgia, arthrosis, muscle cramps, myalgiaPsychiatric: Sexual dysfunction (male and female), insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalizationSkin and appendages: Angioedema, erythema multiforme, pruritus, rash, rash erythematous, rash maculopapularSpecial senses: Abnormal vision, conjunctivitis, diplopia, eye pain, tinnitusUrinary system: Micturition frequency, micturition disorder, nocturiaAutonomic nervous system: Dry mouth, sweating increasedPulmonary edema (higher incidence in heart failure patients)Jaundice and hepatic enzyme elevations (mostly consistent with cholestasis or hepatitis)Symptomatic hypotension is possible, particularly with severe aortic stenosis; owing to gradual onset of action, acute hypotension unlikelyWorsening of angina and acute myocardial infarction (MI) can develop after dose is started or increased, particularly with severe obstructive CADExtensively metabolized by the liver and plasma elimination half-life is 56 hr in patients with hepatic impairment; titrate slowly when treating patients with severe hepatic impairmentLimited available data based on postmarketing reports are insufficient to inform a drug-associated risk for major birth defects and miscarriage during pregnancyLimited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated median relative infant doseNo adverse effects of amlodipine on breastfed infant reportedThere is no available information on effects of amlodipine on milk productionA: Generally acceptable.
Unable to load your delegates due to an error This site needs JavaScript to work properly. Safely reducing doses may prove effective for reducing side effects. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. Usual Adult Dose for Hypertension. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

Ethinyl estradiol is a CYP3A4 substrate.

Pharmacokinetics of amlodipine are not significantly affected by renal impairment; therefore no dosage adjustment necessary; Hepatic impairment. Elsevier Science Lower initial dose may be required for patients with hepatic impairment; Consider starting with 2.5 mg/day PO

Ruilope LM, Malacco E, Khder Y, Kandra A, Bönner G, Heintz D.Clin Ther.

Rarely, excessively low blood pressure may be experienced by some people.

Follow your doctor's orders or the directions on the label.
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. There was no effect on the fertility of rats treated with amlodipine (males for 64 days and females 14 days prior to mating) at doses up to 10 mg/kg/day (8 times* the maximum recommended human dose of 10 mg on a mg/m 2 basis).

Diseases & Conditions katerzia-norvasc-amlodipine-342372 Diseases & Conditions Norvasc is usually available in 2.5 and 5 mg tablets. Amlodipine a prescription medication that is used with or without other medications to treat high blood pressure.Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems. 2184611-overview The dose of this medicine will be different for different patients.

Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1.

Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding amlodipine besylate tablets to other antihypertensive therapy. Dosage Modifications Renal impairment. Follow your doctor's orders or the directions on the label.

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