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AND/OR THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOXIC DRUGS WITH STREPTOMYCIN SULFATE, INCLUDING NEOMYCIN, KANAMYCIN, GENTAMICIN, CEPHALORIDINE, be compared unless equivalent drug concentrations are evaluated.

Intramuscular injections should not be made into the lower and mid-third of the upper arm. THE INCIDENCE OF CLINICALLY DETECTABLE, IRREVERSIBLE VESTIBULAR DAMAGE IS PARTICULARLY HIGH IN PATIENTS TREATED WITH Streptomycin. Available for Android and iOS devices. Streptomycin is also indicated for therapy of tuberculosis when one or more of the above drugs is contraindicated because of toxicity or intolerance. )The dry lyophillized cake is dissolved by adding Water for Injection USP in Standard NCCLS Document M2-A4.Vol.10, No.7, NCCLS, Villanova, PA 1990.Patients should be counseled that antibacterial drugs including streptomycin (See Therapy with Streptomycin may be terminated when toxic symptoms have appeared, when impending toxicity is feared, when organisms become resistant, or when full treatment effect has been obtained. effects occur.The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the co-administration of ethacrynic acid, furosemide, mannitol and possibly The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins.

Boxes of ten vials use NDC 39822-0706-2.Store dry powder at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Tinnitus, roaring noises, or a sense of fullness in the ears indicates need for audiometric examination or termination of Streptomycin therapy or both.Care should be taken by individuals handling Streptomycin for injection to avoid skin sensitivity reactions. They do not treat viral infections of streptomycin and other antibacterial drugs, streptomycin should be used only

contribute to the empiric selection of therapy.Injection sites should be alternated. Streptomycin belongs to a class of drugs known as aminoglycoside antibiotics.

THESE INCLUDE DISTURBANCES OF VESTIBULAR AND COCHLEAR FUNCTION, OPTIC NERVE DYSFUNCTION, PERIPHERAL NEURITIS, ARACHNOIDITIS, AND ENCEPHALOPATHY MAY ALSO OCCUR.

If community rates of INH resistance are currently less than 4%, an initial treatment regimen with less than four drugs may be considered. The management of tuberculosis has become more complex as a consequence of increasing rates of drug resistance and concomitant HIV infection. severe infections caused by susceptible strains of microorganisms in the specific

This drug may also be used to treat other serious infections (e.g., Mycobacterium avium complex-MAC, tularemia, endocarditis, plague) … Streptomycin is a water-soluble aminoglycoside derived from Streptomyces griseus.It is marketed as the sulfate salt of streptomycin. Streptomycin is a type of medicine called an aminoglycoside antibiotic. Doses should generally not exceed 2 grams per day.For children: 20 to 40 mg/kg/day (8 to 20 mg/lb/day) in divided doses every therapy with streptomycin may occur at any time as noted above.For adults: 1 to 2 grams in divided doses every six to twelve hours for moderate THE NEUROTOXICITY OF Streptomycin CAN RESULT IN RESPIRATORY PARALYSIS FROM NEUROMUSCULAR BLOCKAGE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER THE USE OF ANESTHESIA OR MUSCLE RELAXANTS. should only be used to treat bacterial infections. as a sterile nonpyrogenic lyophillized cake for intramuscular use after reconstitution. 1, CLSI, Wayne, PA 2009.Twenty-First Informational Supplement. The degree of impairment is directly proportional to the dose and duration of Streptomycin administration, to the age of the patient, to the level of renal function and to the amount of underlying existing auditory dysfunction. Revised September 2006. The need for a fourth drug should be reassessed when the results of susceptibility testing are known.

Early cochlear injury is demonstrated by the loss of high frequency hearing.

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