Erectile dysfunction (ED) can have several causes. Thank you for visiting nature.com. Angiotensin-converting enzyme (ACE) inhibitors help relax blood vessels. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in International Journal of Impotence Research ACE inhibitors have a valuable role to play in patients who have hypertension and erectile dysfunction. and JavaScript.The involvement of antihypertensive therapy in the pathology of hypertension associated male erectile dysfunction is unclear. It should not be used for medical advice, diagnosis or treatment. To obtain For instance, ACE inhibitors … ACE inhibitors prevent an enzyme in your body from producing angiotensin II, a substance in your body that narrows your blood vessels and releases hormones that can raise your blood pressure. Rather than paying attentionA spinal cord injury can cause erectile dysfunction. Sexual dysfunction related to antihypertensive agents: results from the animal model El Mabrouk M, Touyz RM, Schiffrin EL . A study of arterial risk factors in 440 impotent men Benson CB, Vickers MA . Depending on the severity of the injury, it may You are using a browser version with limited support for CSS. SHRSP-placebo treated rats were hypertensive and had a blunted erectile response. Speak with your doctor to determine whether your ED may be caused by poor circulation, diabetes, obesity, smoking, medication side effect or stress and anxiety. The possibility that this is due to a reduction in smooth muscle cell proliferation and contraction warrants further investigation.Bansal A . ACE is responsible both for the production of angiotensin II, a vasoconstrictor, and the degradation of bradykinin, a vasodilator. Therefore, ACE inhibitor therapy may not be responsible for the erectile dysfunction observed in treated hypertensive subjects.Penile erection occurs when the vascular smooth muscle cells, located in the cavernosal arterioles and cavernous sinuses relax, leading to an increase in blood flow into the cavernous sinuses under the driving force of mean arterial pressure (MAP). In the meantime, to ensure continued support, we are displaying the site without styles The voltage dependant increase in ICP/MAP was significantly decreased in placebo treated SHRSP compared to control normotensive rats at 4 and 5 volts simulation (Effect of voltage stimulation of the major pelvic ganglion on ICP/MAP.

Vascular remodeling: The role of angiotensin converting enzyme inhibitors Srilatha B, Adaikan PG, Arulkumaran S, Ng SC . All rats were maintained on a 12-hour light dark cycle and were allowed access to normal rat chow The methods used to measure intracavernosal pressure and mean arterial pressure have been described previously.Data were analyzed using analysis of variance (ANOVA) with post-hoc comparisons made by Student Newman Keul's test. Statistical significance was set at Treatment of SHRSP from six weeks to twelve weeks of age with captopril significantly reduced the systolic blood pressure (109±5.2 The responsiveness of the vasculature to the stimulation of the major pelvic ganglion was assessed by measurement of ICP/MAP.

Sexual dysfunction in hypertensive men: A critical review of the literature Weiss RJ . Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR Hale TM, Okabe H, Heaton JPW, Adams MA . The voltage dependant increase in ICP/MAP was significantly increased in captopril treated SHRSP compared to placebo treated SHRSP at 4 and 5 volts simulation (This study confirms in an animal model of essential hypertension the link between hypertension and erectile dysfunction. Both of these vasoactive mechanisms have been shown to be active in the human corpus cavernosum.This study would suggest that ACE inhibitors do not have deleterious effect in erectile function in rats despite a marked reduction in mean arterial pressure. Also, the study suggests that treatment of hypertension with an ACE inhibitor is beneficial to the erectile dysfunction.

You can also search for this author in The substudy of the ONTARGET/TRANSCEND trials evaluates the relationship of erectile function to baseline characteristics and current treatment in cardiovascular high-risk patients who have been enrolled in these trials.

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