may be associated with a reversible delay in Inform pregnant women to avoid use of VOLTAREN and other NSAIDs, starting at 30 weeks gestation because of the risk of the premature closure of the fetal Inform patients that the concomitant use of VOLTAREN with other NSAIDs or salicylates (e.g., diflunisal, salsalate) is not recommended due to the increased risk of gastrointestinal toxicity, and little or no increase in efficacy (see Inform patients not to use low-dose aspirin concomitantly with VOLTAREN until they talk to their healthcare provider (see The pharmacological activity of VOLTAREN in reducing inflammation, and possibly fever, may diminish the utility of diagnostic signs in detecting infections.Because serious GI bleeding, hepatotoxicity, and renal injury can occur without warning symptoms or signs, consider monitoring patients on long-term NSAID treatment with a Long-term carcinogenicity studies in rats given diclofenac sodium up to 2 mg/kg/day (approximately 0.1 times maximum recommended human dose (MRHD) of VOLTAREN, 200 mg/day, based on Diclofenac sodium did not show mutagenic activity in Diclofenac sodium administered to male and female rats at 4 mg/kg/day (approximately 0.2 times the MRHD based on BSA comparison) did not affect fertility.Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including VOLTAREN, may delay or prevent Use of NSAIDs, including VOLTAREN, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. The optimum times for making the first and subsequent transaminase measurements are not known. Cautions. Subject: Update to cardiovascular safety information and decrease in recommended maximum daily dose for all systemic formulations of diclofenac-containing medicines including VOLTAREN ® / VOLTAREN ® SR (diclofenac sodium), VOLTAREN RAPIDE ® (diclofenac potassium), and ARTHROTEC ® (diclofenac sodium/misoprostol). May result in bleeding, death; monitor anticoagulant response (e.g., INR) and adjust anticoagulant dose accordingly Do not use the cream just before of after heart surgeries.--- stomach upset including nausea (feeling sick), vomiting, indigestion, cramps, loss of appetite, wind; heartburn or pain behind or below the breastbone (possible symptoms of an ulcer in the tube that carries food from the throat to the stomach); stomach or abdominal pain; constipation, diarrhoea; sore mouth or tongue; altered taste sensation; headache; dizziness, spinning sensation; drowsiness, disorientation, forgetfulness; feeling depressed, anxious or irritable; strange or disturbing thoughts or moods; shakiness, sleeplessness, nightmares; tingling or numbness of the hands or feet; feeling of fast or irregular heart beat; unusual weight gain or swelling of arms, hands, feet, ankles or legs due to fluid build-up; symptoms of sunburn (such as redness, itching, swelling, blistering of the lips, eyes, mouth, and/or skin) that happen more quickly than normal; skin inflammation with flaking or peeling; vision disorders* (e.g. You must select at least

If VOLTAREN is used in patients with severe heart failure, monitor patients for signs of worsening heart failure.Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal No information is available from controlled clinical studies regarding the use of VOLTAREN in patients with advanced renal disease.

Voltaren Tablets dosage: For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary.

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