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You may report side effects to Health Canada at 1-866-234-2345.If someone has overdosed and has serious symptoms such as passing out or Information last revised July 2016.

Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.Propranolol can pass into breast milk and may harm a nursing baby. The optimum duration of maintenance Imuran has not been determined. The cytotoxicity of azathioprine is due, in part, to the incorporation of 6-TGN into DNA.6-MP undergoes two major inactivation routes. The incidence of lymphoproliferative disease in patients with RA appears to be significantly higher than that in the general population. Azathioprine is immunosuppressive, delayed hypersensitivity and cellular cytotoxicity tests being suppressed to a greater degree than are antibody responses.

Patients with rheumatoid arthritis previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, or others) may have a prohibitive risk of malignancy if treated with Imuran.Renal transplant patients are known to have an increased risk of malignancy, predominantly skin cancer and reticulum cell or lymphomatous tumors. (Inderal is a brand name of the drug propranolol, a beta-blocker used to prevent heart attacks, and also for the treatment of chronic migraine headaches.)

Follow all directions on your prescription label. Because of the risk of toxicity, patients with TPMT or NUDT15 deficiency require alternative therapy or dose modification (see DOSAGE and ADMINISTRATION).Approximately 0.3% (1:300) of patients of European or African ancestry have two loss-of-function alleles of the TPMT gene and have little or no TPMT activity (homozygous deficient or poor metabolizers), and approximately 10% of patients have one loss-of-function TPMT allele leading to intermediate TPMT activity (heterozygous deficient or intermediate metabolizers). You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Propranolol används för att behandla skakningar, angina (bröstsmärtor), hypertoni (högt blodtryck), hjärtrytmrubbningar och andra tillstånd i hjärtat eller cirkulationen. UpToDate: UpToDate 連結: 藥理作用: 可刺激上消化道的運動，加速胃部及十二指腸排空，並抑制嘔吐中樞，減緩嘔吐 … Azathioprine is chemically 6-[(1-methyl-4-nitro-1 H-imidazol-5-yl)thio]-1 H-purine. However, the proportion of the increased risk attributable to the azathioprine dosage or to other therapies (i.e., alkylating agents) received by patients treated with azathioprine cannot be determined.Patients with low or absent TPMT or NUDT15 activity are at increased risk for severe, life-threatening myelosuppression from Imuran (see CLINICAL PHARMACOLOGY, WARNINGS: Cytopenias and PRECAUTIONS: Laboratory Tests, DOSAGE AND ADMINISTRATION).Maintenance therapy should be at the lowest effective dose, and the dose given can be lowered decrementally with changes of 0.5 mg/kg or approximately 25 mg daily every 4 weeks while other therapy is kept constant. TPMT activity correlates inversely with 6-TGN levels in erythrocytes and presumably other hematopoietic tissues, since these cells have negligible xanthine oxidase (involved in the other inactivation pathway) activities.Genetic polymorphisms influence TPMT and NUDT15 activity. Physicians should inform patients of the risk of malignancy with Imuran. Sin embargo, cualquier persona con un trastorno autoinmune inflamatorio puede tener un mayor riesgo de linfoma. Prompt reduction in dosage or temporary withdrawal of the drug may be necessary if there is a rapid fall in or persistently low leukocyte count, or other evidence of bone marrow depression. Do not take this medicine in larger or smaller amounts or for longer than recommended.Adults may take Inderal with or without food, but take it the same way each time.If you need surgery, tell the surgeon ahead of time that you are using Inderal. Each scored tablet contains 50 mg azathioprine and the inactive ingredients lactose, magnesium stearate, potato starch, povidone, and stearic acid.

If generic versions of this product have been approved by the FDA, there may be Inderal (propranolol) is a beta-blocker. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Do této sekce jsme vložili některé užitečné informace týkající se generických pilulek obecně a informace o jednotlivých lécích najdete potom v našem seznamu produktů. This medicine is used alone or with other medicines. The principal and potentially serious toxic effects of azathioprine (the active ingredient contained in Imuran) are hematologic and gastrointestinal.


Patients receiving immunosuppressants, including Imuran, are at increased risk of developing lymphoma and other malignancies, particularly of the skin. In transplant patients, consider the risk that the reduced immunosuppression represents to the graft.Imuran has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose Imuran is teratogenic in rabbits and mice when given in doses equivalent to the human dose (5 mg/kg daily).

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