The mouthpiece is reusable and should be cleaned regularly with soap and water. In clinical trials, the average daily dose was >6 (range 3 to 18) cartridges for patients who successfully quit smoking. Withdrawal symptoms such as cigarette craving can be reduced in most individuals by plasma nicotine levels lower than those from smoking.Withdrawal from nicotine in addicted individuals can be characterized by craving, nervousness, restlessness, irritability, mood lability, anxiety, drowsiness, sleep disturbances, impaired concentration, increased appetite, minor somatic complaints (headache, myalgia, constipation, fatigue), and weight gain. Repeated doses of activated charcoal should be administered as long as the cartridge remains in the gastrointestinal tract since it will continue to release nicotine for many hours.

The incidence of adverse events is confounded by: (1) the many minor complaints that smokers commonly have, (2) continued smoking by many patients and (3) the local irritation from both the active drug and the placebo.NICOTROL Inhaler and the placebo were both associated with local irritant side effects. After use of the single inhaler the arterial nicotine concentrations rise slowly to an average of 6 ng/mL in contrast to those of a cigarette, which increase rapidly and reach a mean CThe temperature dependency of nicotine release from the NICOTROL Inhaler was studied between 68°F and 104°F in eighteen patients. Other forms of nicotine replacement might be preferable in patients with severe bronchospastic airway disease.The risks of nicotine replacement in patients with cardiovascular and peripheral vascular diseases should be weighed against the benefits of including nicotine replacement in a smoking cessation program for them. Only severe renal impairment would be expected to affect the clearance of nicotine or its metabolites from the circulation (See Nicotrol Inhaler therapy should be used with caution in patients with hyperthyroidism, pheochromocytoma or insulin-dependent diabetes, since nicotine causes the release of catecholamines by the adrenal medulla.Nicotine delays healing in peptic ulcer disease; therefore, Nicotrol Inhaler therapy should be used with caution in patients with active peptic ulcers and only when the benefits of including nicotine replacement in a smoking cessation program outweigh the risks.Nicotine therapy constitutes a risk factor for development of malignant hypertension in patients with accelerated hypertension; therefore, Nicotrol Inhaler therapy should be used with caution in these patients and only when the benefits of including nicotine replacement in a smoking cessation program outweigh the risks.A patient information sheet is included in the package of Nicotrol Inhaler cartridges dispensed to the patient.
Lethal doses produce convulsions quickly and death follows as a result of peripheral or central respiratory paralysis or, less frequently, cardiac failure.One cartridge of Nicotrol Inhaler contains 10 mg nicotine, of which, approximately 4 mg is delivered nicotine.
An intensive inhalation regimen (80 deep inhalations over 20 minutes) releases on the average 4 mg of the nicotine content of each cartridge of which about 2 mg is systemically absorbed. The Nicotrol Inhaler does not deliver hydrogen cyanide and carbon monoxide. Sexual dysfunction (decreased sex drive and delayed orgasm and ejaculation) has been associated with Cymbalta (duloxetine).

Available for Android and iOS devices. Patients should be instructed to stop smoking completely while using this product. 95 ($17.95/Count) The quit rates are the percentage of all persons initially enrolled who continuously abstained after week 2. Regular use of NICOTROL Inhaler during the first week of treatment may help patients adapt to the irritant effects of the product. However, nicotine has been shown in animal studies to cause fetal harm. An infant has the ability to clear nicotine by hepatic first-pass clearance; however, the efficiency of removal is probably lowest at birth. FOLLOW ALL DIRECTIONS Exactly! The effects of cigarette smoking on fetal cardiovascular parameters have been studied near term.

SuccessIf you are pregnant or breast-feeding, only use this medicine on the advice of your health care provider.BEFORE YOU USE - Read information on both sides. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product (See Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Most successful patients in the clinical trials used between 6 and 16 cartridges a day. Repeated doses of activated charcoal should be administered as long as the cartridge remains in the gastrointestinal tract since it will continue to release nicotine for many hours.

The efficacy is shown in the following table.Patients who used Nicotrol Inhaler had a significant reduction in the "urge to smoke", a major nicotine withdrawal symptom, compared with placebo-treated patients throughout the first week, (see Nicotrol Inhaler is indicated as an aid to smoking cessation for the relief of nicotine withdrawal symptoms.

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