After 1 year of regular use, PSA levels were 1% lower in users of nonsteroidal anti-inflammatory drugs (NSAIDs), 3% lower in statin users, and—an apparently novel observation—6% lower in thiazide diuretic users, according to data reported at a symposium on genitourinary cancers. 5-alpha reductase inhibitors also affect PSA levels. After adjusting for other independent variables that affect PSA levels, prostate size, and cancer risk, PSA values were nearly 9% lower in men who took aspirin compared with those who did not (7.3 vs. 8.0 ng/mL). They were followed by beta-blockers (13%), angiotensin-converting enzyme (ACE) inhibitors (11%), NSAIDs (9%), proton pump inhibitors (9%), calcium channel blockers (6%), selective serotonin reuptake inhibitors (6%), thiazide diuretics (5%), alpha-blockers (4%), and sulfonylureas (4%). Chang and his colleagues studied the effect of 10 common medications on PSA test readings in 1,864 men age 40 and older with no history of prostate cancer.

Stanford urologist James Brooks clarifies some misconceptions. While herbals treatments are som… PSA can determine the presence of prostate cancer, benign prostatic hypertrophy and prostatitis. On the other hand, statins are known to produce lower readings. Prostate specific antigen, or PSA is a protein produced by the prostate that is found in semen 2. Statins topped the list of the 10 medications most commonly used in the study cohort (taken by 20% of the men), according to study results, which were reported in a poster session. Every 10% decrease in LDL was accompanied by a 1.64% decrease in PSA. The good thing would be if the drugs were actually putting the brakes on prostate-cancer development. // Leaf Group Lifestyle I take it for a short time prior to the PSA test not to “mask” my PSA … Drugs such as aspirin, ibuprofen and naproxen are commonly used pain relievers.

Find out what foods, nutrients, and other natural sources may actually help reduce your levels. The drugs, finasteride and dutasteride, can lower prostate-specific antigen (PSA) levels by about 50 percent. If any of these medications actually affect prostate cells, perhaps they may have a role in prevention or therapy of prostatic diseases.” “If taking these medications alters serum PSA, it could affect the quality of prostate cancer screening,” said lead investigator Dr. Steven L. Chang. Saw palmetto is often used to treat the symptoms of BPH. Prostate specific antigen or PSA is a specific antigen produced by the prostate. “In that case, patients who develop prostate cancer would be identified later because their PSA levels would be lower than in others (all other things being equal) who are not on these medications,” Dr. Chang observed. The association appeared to be direct. That could give the false impression that a patient is fine when, in fact, an underlying problem has merely been masked by the drug effect. If not taken into account, this can interfere with the results of PSA tests to detect prostate cancer. I have a history of prostatitis and we all know that can raise PSA levels temporarily. In multivariate analyses, PSA levels after 1 year of regular use were 1% lower in NSAID users (The effects of statins and NSAIDs on PSA have been previously reported, but the finding for thiazide diuretics appears to be new and was somewhat surprising in magnitude, Dr. Chang commented in an interview at the symposium, which was sponsored by the American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Urologic Oncology. Her health care experience includes pediatrics, geriatrics, and mental health. The bad thing would be if the drugs were doing something that caused PSA levels in the blood to drop without, however, having any negative effect on prostate-tumor formation or growth. The difference in PSA levels among users and nonusers of the common medications increased over time, with reductions of 6%, 13%, and 26% seen with 5 years of regular use of NSAIDs, statins, and thiazide diuretics, respectively. Some studies have shown NSAID’s may reduce inflammation. The association appeared to be direct. 3 Recent studies suggest that other medications, including statins 4–6 and nonsteroidal anti-inflammatory drugs (NSAIDs), 7 may also lower PSA levels. PSA, or prostate-specific antigen, is a protein produced by cells in your prostate gland. Statins and PSA . PSA testing is an important tool to spot prostate cancer, but it remains a bit confusing. “Many men take NSAIDs for their cardiovascular health, so we need to know whether these agents reduce prostate cancer risk or simply reduce PSA, which would then be even less reliable as a marker of prostate cancer risk,” notes lead investigator Jay H. Fowke, PhD, assistant professor of medicine at Vanderbilt University School of Medicine.Please login or register first to view this content.Copyright © 2020 Haymarket Media, Inc. All Rights ReservedRegister now at no charge to access unlimited clinical news Please login or register first to view this content.

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