Tags. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow).Theophylline increases the force of contraction of diaphragmatic muscles.
The dosage is based on your medical condition, response to treatment, age, weight, lab tests (theophylline blood levels), and other medications you may be taking. Aminophylline systemic 100 mg (West-Ward 020) Quad tabs® are scored twice for maximum flexibility in dosing and dispensing. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration.

At serum theophylline concentrations > 20 mcg/mL, both the frequency and severity of adverse reactions increase. Discontinuation of a concomitant drug that increases theophylline clearance will result in accumulation of theophylline to potentially toxic levels, unless the theophylline dose is appropriately reduced.
The dosage strength is the strength of 1 tablet. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in elderly patients (see The clearance of theophylline is very low in neonates (see  Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance. Theophylline has also been shown to reduce the need for short courses of daily oral prednisone to relieve exacerbations of airway obstruction that are unresponsive to bronchodilators in asthmatics.In patients with chronic obstructive pulmonary disease (COPD), clinical studies have shown that theophylline decreases dyspnea, air trapping, the work of breathing, and improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements.Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.Aminophylline Tablets are contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product including ethylenediamine.Theophylline should be used with extreme caution in patients with the following clinical conditions due to the increased risk of exacerbation of the concurrent condition:There are several readily identifiable causes of reduced theophylline clearance. Initial dose: 300 mg per day given as evenly divided doses every 6 to 8 hours After 3 days, if starting dose was tolerated: 400 mg per day given as evenly divided doses every 6 to 8 hours After 3 more days, if tolerated: 600 mg per day given as evenly divided doses every 6 to 8 hours Extended Release Tablets (400 or 600 mg): More frequently, however, the interaction is pharmacokinetic, i.e., the rate of theophylline clearance is altered by another drug resulting in increased or decreased serum theophylline concentrations. Different rates of elimination and consequent dosage requirements have been observed among other peoples. 0.4-0.6 mg/kg/hr IV or 4.8-7.2 mg/kg PO (extended release) q12hr to maintain levels 10-15 mg/L ; Smokers: 0.79 mg/kg/hr IV for next 12 hours after loading dose, then 0.63 mg/kg/hr or 5 mg/kg PO (extended release) q8hr

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