14 Importantly, bedaquiline possesses a selectivity index of >20 000 for mycobacterial ATP synthase versus eukaryotic mitochondrial ATP synthase. This worries me – terms like ‘miracle drug’ should not be used lightly as it can raise expectations and also encourage abuse. Common side effects include problems with vision, joint pain, nausea, … Bedaquiline fumarate is a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid.It is used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. Bedaquiline (BDQ) is a recently approved fast-tracked antibiotic for the treatment of multidrug-resistant tuberculosis (MDR-TB).There have been a few reports of BDQ use in a non-trial setting from Europe. e Structure of oligomycin A, B, and C. f Structure of bedaquiline. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B978044453717100069XURL: https://www.sciencedirect.com/science/article/pii/B9781455748013002514URL: https://www.sciencedirect.com/science/article/pii/S0378608016300307URL: https://www.sciencedirect.com/science/article/pii/S0378608015000185URL: https://www.sciencedirect.com/science/article/pii/B9780702062858001489URL: https://www.sciencedirect.com/science/article/pii/S0065774319300089URL: https://www.sciencedirect.com/science/article/pii/S0065774319300028URL: https://www.sciencedirect.com/science/article/pii/B9780128013175000098URL: https://www.sciencedirect.com/science/article/pii/S0065774319300053URL: https://www.sciencedirect.com/science/article/pii/B9780323448871000304Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition)A Worldwide Yearly Survey of New Data in Adverse Drug ReactionsA worldwide yearly survey of new data in adverse drug reactionsMedicinal Chemistry Approaches to Tuberculosis and TrypanosomiasisStructural characteristics that are seldom found in other bioactive compounds.Combination of these drugs with other antituberculosis agents are currently in clinical trials.Medicinal Chemistry Approaches to Tuberculosis and TrypanosomiasisTackling the Problem of Tuberculosis by NanotechnologyNanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious DiseasesMedicinal Chemistry Approaches to Tuberculosis and TrypanosomiasisStacey L. Martiniano MD, ... Charles L. Daley MD, in Kendig's Disorders of the Respiratory Tract in Children (Ninth Edition)Several additional drugs have been used to treat NTM infections, including fluoroquinolones, clofazimine, inhaled amikacin, linezolid, and Principles and Practice of Pediatric Infectious Diseases (Fifth Edition)Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition)ScienceDirect ® is a registered trademark of Elsevier B.V. SIRTURO ® is the first anti-TB drug to interfere with bacterial energy metabolism.. SIRTURO ® specifically inhibits mycobacterial ATP (adenosine 5'-triphosphate) synthase, by binding to subunit c of the enzyme that is essential for the generation of …

Tuberculosis (TB), the leading cause of death by infectious disease worldwide, is increasingly resistant to first line antibiotics. Mutations in drug Bedaquiline was described for the first time in 2004 at the Interscience Conference on Antimicrobial Agents and Chemotherapy (Bedaquiline was approved for medical use in the United States in 2012.When it was approved by the FDA on 28 December 2012, it was the first new medicine for TB in more than forty years.In 2016, the WHO came under criticism for recommending it as an essential medicine.Brc1ccc2nc(OC)c(cc2c1)[C@@H](c3ccccc3)[C@](O)(c5c4ccccc4ccc5)CCN(C)CInChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

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