[PubMedBork K, Benes P. Concentration and kinetic studies of intravenous acyclovir in serum and breast milk of a patient with eczema herpeticum. [1]A woman who was 1 year postpartum was taking acyclovir 200 mg orally 5 times daily.
[PubMed [PubMedTaddio A, Klein J, Koren G. Acyclovir excretion in human breast milk. Used to treat high blood pressure and Raynaud's syndrome of the nipple: Penicillin, amoxicillin (Dynapen) Antibiotics used to treat bacterial infections: Propranolol (Inderal) A beta-blocker used to treat heart problems and high blood pressure: Theophylline (Theo-Dur) Used to treat asthma and bronchitis: Tretinoin (Retin-A) Topical acne cream.
Acetaminophen or ibuprofen may be safer for pain relief.Some expert opinion indicates that low-dose (75 to 325 mg daily) aspirin may be used as a blood thinning agent for use in breastfeeding women who require it.Avoid high-dose, long-term use of aspirin, if possible.Found in coffee (80-150 mg per 6 ounce cup), tea, soft drinks, energy drinks, chocolate, guarana, some OTC medications.Excess caffeine in the mother can lead to stimulation in infants.
Controlling high blood pressure is therefore one of the most important public health measures for a healthy and enjoyable quality of life through the senior years. Regul Toxicol Pharmacol.
1991;164:569-76. Pharmacokinetics of acyclovir in the term human pregnancy and neonate.
It’s also available as a generic drug. Milk levels taken immediately before a dose during 5 days of therapy ranged from 0.78 to 1.07 mg/L.
It is widely accepted that human milk is best for an infant. [PubMedLau RJ, Emery MG, Galinsky RE. Acyclovir in human breast milk.
Pediatrics.
Am J Obstet Gynecol. Avoid taking unnecessary medications, such as herbal medications, high-dose vitamins and unusual supplements. The authors estimated that a fully breastfed infant would receive a daily dosage of 0.73 mg/kg of acyclovir at this maternal dosage or about 1% of the maternal weight-adjusted dosage. We comply with the HONcode standard for trustworthy health information - Watch for irritability in newborn.Avoid concentrated energy drinks, pure caffeine tablets.Caffeine consumption of 300 mg per day max suggested (2 to 3 cups of coffee).Caffeine levels from breast milk may be higher in preterm infants.Most cephalosporins are considered compatible with breastfeeding.May interfere with gut flora in infant leading to diarrhea or thrush.Poor oral bioavailability, unlikely to adversely affect the breastfed infant.Generic, lower cost versions of norethindrone are available.Estrogen may lower milk production and protein content.Nonhormonal methods are preferred during breastfeeding; however, progestin-only contraceptives such as norethindrone are considered the hormonal contraceptives of choice during lactation.Rx; used to treat inflammation of joints and other conditions.Recommended over oral decongestants, which may inhibit milk production.If given intravenously, avoid breastfeeding for 2 hours after dose.Monitor infant for diarrhea, candidiasis (thrush, diaper rash).Acceptable in nursing mothers because amounts in breastmilk are less than infant dose.Not expected to be appreciably excreted into breastmilk or absorbed by the infant due to high molecular weights.Rx; for diabetes; dosage required may drop up to 25 percent during lactation.Insulin, including newer biosynthetic insulins (aspart, detemir, glargine, glulisine, lispro) is a protein that is inactivated and destroyed in the digestive tract of the infant if taken by mouth.Lidocaine is not expected to cause side effectds in breastfed infants.OTC; non-drowsy antihistamine for allergies and hay fever.Not expected to cause adverse effects in nursing infants.Rx; used for prevention and control of seizures in pre-eclampsia and eclampsia.Postpartum IV use longer than 6 hours may delay onset of lactation.Poor oral bioavailability. No reports list sedation in infants at normal maternal doses.Rx; used for hyperthyroidism (high thyroid levels).When possible, take methimazole immediately after nursing and wait for 3 to 4 hours before nursing again.No cases of thyroid dysfunction have been reported in nursing infants.Not expected to cause adverse effects in most breastfed infants.Expert panels suggest waiting for at least 4 hours after a single IV dose of midazolam before nursing.However, because of naproxen's long half-life and reported serious adverse reaction in a breastfed newborn, other NSAIDs (i.e., ibuprofen) or acetaminophen may be preferred while nursing a newborn or preterm infant.Low levels in breast milk. Toxnet.
Dosages received in breastmilk with high maternal doses are only about 3 to 5% of this dose.
A group of researchers evaluated all existing evidence to determine the strength of the impact of breastfeeding on high blood pressure in women. The peak level was 7.3 mg/L and the drug was detectable in milk for up to 88 hours after the last dose.
Because the infant receives breastmilk doses orally and acyclovir is only about 20% orally bioavailable,[5] the systemic dosage that the nursing infant receives is 1% or less of a typical infant dosage.The mother of a 4-month-old infant noticed no adverse effects in her breastfed infant while she was taking an acyclovir dosage of 800 mg orally 5 times daily. For example, some beta-blockers are found in breast milk in higher amounts and may not be ideal to take when breastfeeding.
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