Emesis and mydriasis were observed within 15 minutes to one hour after dosing in dogs receiving 12.5, 50, and 100 mg/kg/day and lethargy was observed within 1 hour of dosing in dogs receiving 50 and 100 mg/kg. In overdoses, signs such as vomiting, lethargy or depression, weakness and incoordination, dilated pupils, and vocalization may occur. Store unused tablets in the original closed container.Clomicalm Tablets are available in 5, 20, 40 and 80 mg tablet strengths in color-coded packaging for oral administration to dogs.Manufactured for:       Novartis Animal Health US, Inc.Clomicalm is a registered trademark of Novartis AG.

Clomicalm Tablets 5mg is for use in the treatment of separation-related disorders in dogs. Federal (USA) Law restricts this drug to use by or on the order of a licensed veterinarian.Novartis Animal Health US, Inc. encourages you to take the time to read this package insert which describes the use of Clomicalm Tablets for the treatment of separation anxiety in conjunction with behavior modification (training) in dogs. In children, accidental ingestion should be regarded as serious. Continued behavior training is recommended, even after cessation of drug therapy.Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C). Keep out of reach of children. Clomicalm Tablets should not be used in breeding male dogs (see Contraindications). Instead, put dry herbs inside a toy or small pillow, or use a professionally formulated liquid product so that cats can safely benefit from the relaxing qualities of calming leaves and flowers. Because of its anticholinergic properties, clomipramine should be used with caution in patients with increased intraocular pressure, a history of narrow angle glaucoma, urinary retention or reduced gastrointestinal motility. In case of accidental ingestion seek medical attention immediately. If a dose is missed, the next dose should be administered (without doubling) at the next scheduled dosing time.Your veterinarian may decrease the dose or discontinue treatment with Clomicalm Tablets depending on your dog’s response to treatment. Liver disease has occurred, especially in the presence of preexisting conditions or with concurrent administration of drugs metabolized by the liver. In a six month target animal safety study, beagle dogs were dosed daily at 4 (1X), 12 (3X), and 20 (5X) mg/kg/day. KEEP OUT OF REACH OF CHILDREN. TPLO (Tibial Plateau Leveling Osteotomy) in Dogs. You must inform your veterinarian of any current or future medications you are administering to your dog. In an overdose situation, seek veterinary attention for your pet as soon as possible.The safety and efficacy of Clomicalm Tablets have not been established in dogs less than 6 months of age or in pregnant or lactating female dogs. What is clomipramine? Consult with your veterinarian if your dog experiences these or any other conditions.In case of accidental human ingestion or accidental overdose in dogs, call 1-800-637-0281.The recommended daily dose of Clomicalm Tablets is 2 to 4 mg/kg/day (0.9 –1.8 mg/lb/day) (see dosing table below). Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) may be alleviated by the use of Clomicalm Tablets in conjunction with behavior modification.Separation anxiety is a complex behavior disorder displayed when the owner (or other attachment figure) leaves the dog. Total Ear Canal Ablation and Ventral Bulla Osteotomy (TECA) for End-Stage Ears in Dogs and Cats. Plasma levels of closely related tricyclic antidepressants have been reported to be decreased by the concomitant administration of hepatic enzyme inducers (e.g. Clomipramine should be given according to your veterinarian’s instructions. After reading this insert, if you have any questions about the use of Clomicalm Tablets, please consult your veterinarian.Clomicalm (clomipramine hydrochloride) Tablets belong to the dibenzazepine class of tricyclic antidepressants.

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