SUSTIVA est indiqué en association avec d'autres antirétroviraux dans le traitement de l'infection par le virus-1 de l'immunodéficience humaine (VIH-1) chez l'adulte, l'adolescent et l'enfant de 3 mois et plus et pesant au moins 3,5 kg. Safety and efficacy have not been established.Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of efavirenz in the elderly. We also discuss how efavirenz interacts with the brain and review recently identified cellular mechanisms that may be implicated.Like the other NNRTIs—nevirapine, etravirine and rilpivirine—efavirenz is effective without the need for intracellular metabolism; it restricts viral replication by binding non-competitively to the hydrophobic region of the HIV-1 reverse transcriptase through an allosteric mechanism that alters the enzyme conformation and prevents access to the substrates.The general characteristics of efavirenz are summarized in Table General and pharmacokinetic characteristics of efavirenzGeneral and pharmacokinetic characteristics of efavirenzPlasma concentrations of efavirenz and the influence of CYP2B6 polymorphismsThe table displays examples of clinical studies performed in different settings that reveal a high interindividual variability and presence of subtherapeutic and supratherapeutic plasma levels of efavirenz after the administration of its standard dose. En juillet 2013, le registre des grossesses sous antirétroviraux a répertorié des données prospectives de 904 grossesses exposées à des associations comprenant éfavirenz, au cours du premier trimestre de grossesse, aboutissant à 766 naissances. Les informations portant sur les effets de l'éfavirenz chez les nouveaux-nés et les nourrissons sont insuffisantes. Oxyde de fer (E172) jaune, L'allaitement doit être interrompu pendant le traitement par SUSTIVA. Animal studies performed with cynomolgus monkeys during the development of efavirenz revealed malformations in the CNS when therapeutic doses were administered, particularly anencephaly with unilateral anophthalmia, microphthalmia and cleft palate.Since its approval, over a dozen clinical studies have directly assessed efavirenz side effects and the therapy discontinuation that they provoked (Table CNS adverse events in ACTG and pivotal randomized clinical trials performed in antiretroviral-naive patients receiving efavirenzAEs, adverse events; EFV, efavirenz; IDV, indinavir; ATV, atazanavir; RPV, rilpivirine; ELV/c, elvitegravir/cobicistat; RAL, raltegravir; DLG, dolutegravir.The CNS adverse events reported in these studies vary in terms of their definition and depend on the profile and tolerability of the drug compared with efavirenz. Enveloppe de la gélule :

You should not become pregnant while you are taking efavirenz and for 12 weeks after stopping it. Efavirenz-induced NO participates in (1) the mitochondrial actions and (2) the bioenergetic effect (up-regulation of glycolysis) produced by this drug. You may report side effects to the FDA at 1-800-FDA-1088.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Un patient a éprouvé des contractions musculaires involontaires. Stéarate de magnésium (E572), Une augmentation des concentrations d'éfavirenz observée suite à l'administration de l'éfavirenz avec de la nourriture peut entraîner une augmentation de la fréquence des effets indésirables (voir rubriques Mises en garde spéciales et précautions d'emploi et Propriétés pharmacocinétiques).

All rights reserved. Check with your doctor right away if you or your child are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, a fever, a headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.Efavirenz may increase the level of cholesterol and fats in your blood.

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