Common Brand Names Zithromax No generic products are available.
The two regimens have been described previouslyNo pharmaceutical company was involved in the design of the study, data collection or analysis, or the writing of the manuscript. Schlenk and Platzbecker contributed equally to this article.We thank E.H. Estey (Seattle) and M.A. Sep 8, 2020 Along with other medications, it may also be used for malaria.
Caution should be exercised when azithromycin is administered to patients with severe renal impairment (GFR < 10 ml/min) (see section 4.4 – Special warnings and precautions for use and Section 5.2 Pharmacokinetic properties) Since azithromycin is metabolised in the liver and excreted in the bile, the drug should not be given to patients suffering from severe liver disease. Standardized protocols were used for FISH, 30 RT-PCR assay for PML-RARA 28,29 (sensitivity, 10 −4 [i.e., 1 leukemic cell in 10,000 normal cells]), and immunofluorescence staining for PML.
(Funded by Associazione Italiana contro le Leucemie and others; ClinicalTrials.gov number, Acute promyelocytic leukemia (APL) has become a highly curable disease with contemporary treatment, which consists of all-Arsenic trioxide is also highly effective in the treatment of APL.
Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services.We conducted a phase 3, multicenter trial comparing ATRA plus chemotherapy with ATRA plus arsenic trioxide in patients with APL classified as low-to-intermediate risk (white-cell count, ≤10×10Complete remission was achieved in all 77 patients in the ATRA–arsenic trioxide group who could be evaluated (100%) and in 75 of 79 patients in the ATRA–chemotherapy group (95%) (P=0.12).
The three patients in the ATRA–chemotherapy group died from hemorrhagic shock, pulmonary embolism, and bronchopneumonia.
); Policlinico Universitario Tor Vergata, Rome (Mariadomenica Divona, B.Sc.
Besides the 2 patients who went off protocol during induction therapy, 2 additional patients in the ATRA–arsenic trioxide group were taken off protocol after induction therapy owing to a toxic effect (repetitive tachycardia) and a major protocol violation. ); Dipartimento di Ematologia, Università Campus Biomedico, Rome (Giuseppe Avvisati, M.D., Ph.D.); GIMEMA Data Center (Marco Vignetti, M.D., Sonia Maria Orlando, B.Sc., Paola Fazi, M.D., Franco Mandelli, M.D.)
); Abteilung Hämatologie, Onkologie, Rheumatologie, Immunologie und Pulmologie, Eberhard Karls-Universität, Tübingen (Helmut R. Salih, M.D.
); USC Ematologia Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (Alessandro Rambaldi, M.D.
Since the lower bound of the 95% confidence interval for the difference in event-free survival rates was not lower than −5%, the noninferiority of ATRA–arsenic trioxide was confirmed (P<0.001).
); Dipartimento di Ematologia, Università di Bari, Bari (Giorgina Specchia, M.D.
); Dipartimento di Ematologia, Spedali Civili, Brescia (Elisa Cerqui, M.D. Do not store above 86°F. Orally administered azithromycin is widely distributed over the whole body.Pharmacokinetic studies have shown considerably higher azithromycin concentrations in the tissues (up to 50 times the maximum concentration observed in the plasma) than in the plasma. Hepatic toxic effects appeared to be manageable with temporary discontinuation of the study medication and subsequent dose adjustments; the use of hydroxyurea was sufficient to counteract hyperleukocytosis.Pilot studies of arsenic trioxide as a single agent have shown encouraging results, which were particularly favorable for patients with low-to-intermediate-risk disease.The present study suggests that APL is curable without conventional chemotherapy. In patients receiving both azithromycin and antacids, the drugs should not be taken simultaneously.In healthy volunteers, co-administration of a 5-day regimen of azithromycin with cetirizine 20 mg at steady-state resulted in no pharmacokinetic interaction and no significant changes in the QT interval. Coadministration of azithromycin increased the QTc interval in a dose- and concentration-dependent manner. As compared with ATRA–chemotherapy, ATRA–arsenic trioxide was associated with less hematologic toxicity and fewer infections but with more hepatic toxicity.ATRA plus arsenic trioxide is at least not inferior and may be superior to ATRA plus chemotherapy in the treatment of patients with low-to-intermediate-risk APL.
SAS statistical software, version 9.1.3, was used for all analyses.In the ATRA–arsenic trioxide group, both the patients who did not complete induction therapy and the patient who discontinued treatment after induction therapy owing to a major protocol violation could be evaluated for postconsolidation polymerase-chain-reaction status and event-free survival at 2 years and thus were included in the intention-to-treat analysis. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care.The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams.NEW!
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